卤素键促进3,3-二取代氧吲哚的光诱导合成

IF 3.3 2区化学 Q1 CHEMISTRY, ORGANIC

Journal of Organic Chemistry Pub Date : 2025-04-24 DOI:10.1021/acs.joc.4c02963

Kun-Quan Chen, Jia Zhang, Xiao-Bo Chen, De-Qun Sun

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引用次数: 0

摘要

报道了一种光诱导自由基环化合成3,3-二取代氧吲哚的方法。该方法利用易于获得的α-溴苯胺作为底物，显示出广泛的底物范围。α-溴苯胺与TMG和醇的卤素键形成了光激活的电荷转移配合物，促进了反应机理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Halogen Bonding Promoted Photoinduced Synthesis of 3,3-Disubstituted Oxindoles

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Halogen Bonding Promoted Photoinduced Synthesis of 3,3-Disubstituted Oxindoles

A photoinduced and catalyst-free radical cyclization process for the synthesis of 3,3-disubstituted oxindoles is reported. This method utilizes readily available α-bromoanilides as substrates, showcasing a broad substrate scope. The reaction mechanism is facilitated by a photoactivated charge transfer complex based on the halogen bonding of α-bromoanilide with TMG and alcohol.

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来源期刊

Journal of Organic Chemistry 化学-有机化学

CiteScore

6.20

自引率

11.10%

发文量

1467

审稿时长

2 months

期刊介绍： Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.