超低活度18F-FDG PET/CT长轴视场成像系统的可行性

Charlotte L.C. Smith, Gerben J. C. Zwezerijnen, Marijke E. den Hollander, Josée M. Zijlstra, C. Willemien Menke-van der Houven van Oordt, Idris Bahce, Maqsood Yaqub, Ronald Boellaard
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引用次数: 0

摘要

18F-FDG PET/CT成像在肿瘤学中应用广泛。长轴视场(LAFOV) PET/CT系统具有超高的灵敏度和信噪比,能够显著降低示踪剂活性,缩短采集时间。本研究旨在通过高低活度测试-重测试研究,评估在LAFOV PET/CT系统上进行的18F-FDG PET/CT成像中使用超低活度进行半定量测量的可行性。方法:11例肿瘤患者接受2次18F-FDG PET/CT扫描,第一次为标准活度(3.0 MBq/kg), 7 d内1次为超低活度(0.3 MBq/kg)。对两次扫描的列表模式数据进行重新采样,以模拟0.3和0.03 MBq/kg的活动。半定量测量(SUVmean、SUVpeak和SUVmax)及其在健康器官和病变中的可重复性在不同的活动和重建方案中进行了比较。结果:SUVmean在活性降低和重建方案中保持稳定,而SUVpeak在模拟1%的标准18F-FDG活性时表现出稳定。当18F-FDG活性较低时,SUVmax显著增加,尤其是在临床首选扫描时。可重复性分析表明,即使在0.03 MBq/kg时,SUVmean和SUVpeak的可变性也保持在可接受的范围内(15%),而SUVmax的可变性经常超过这些限制。0.3 MBq/kg时病变检测是可靠的,但0.03 MBq/kg时无法描绘出一些病变,表明图像质量受损。结论:利用超低18F-FDG活性(0.3 MBq/kg)在LAFOV PET/CT系统上进行PET/CT成像是可行的,半定量测量、可重复性分析、病变可检测性和半自动化描绘方法均证明了这一点。这些发现支持将辐射暴露水平保持在合理或实际可达到的最低水平的成像方案,这对辐射敏感患者(如儿童、孕妇)尤其重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Feasibility of Ultra-Low-Activity 18F-FDG PET/CT Imaging Using a Long–Axial-Field-of-View PET/CT System

18F-FDG PET/CT imaging is widely used in oncology. Long–axial-field-of-view (LAFOV) PET/CT systems exhibit ultrahigh sensitivity and signal-to-noise ratios, enabling significant reductions in tracer activity and shorter acquisition times. This study aimed to evaluate the feasibility of using ultralow activities for semiquantitative measurements in 18F-FDG PET/CT imaging performed on an LAFOV PET/CT system through a high–low activity test–retest study. Methods: Eleven oncology patients underwent 2 18F-FDG PET/CT scans, the first with standard activity (3.0 MBq/kg) and, within 7 d, 1 with ultralow activity (0.3 MBq/kg). List-mode data of both scans were resampled to simulate activities of 0.3 and 0.03 MBq/kg. Semiquantitative measurements (SUVmean, SUVpeak, and SUVmax) and their repeatability in healthy organs and lesions were compared across different activities and reconstruction protocols. Results: SUVmean remained stable across activity reductions and reconstruction protocols, whereas SUVpeak showed stability except when simulating 1% of the standard 18F-FDG activity. SUVmax significantly increased at lower 18F-FDG activities, particularly with clinically preferred scans. Repeatability analysis showed that SUVmean and SUVpeak maintained variability within acceptable limits (<15%) even at 0.03 MBq/kg, whereas SUVmax variability often exceeded these limits. Lesion detection was reliable at 0.3 MBq/kg, but several lesions could not be delineated at 0.03 MBq/kg, indicating compromised image quality. Conclusion: The use of ultralow 18F-FDG activity (0.3 MBq/kg) is feasible for PET/CT imaging on an LAFOV PET/CT system, as shown by semiquantitative measurements, repeatability analyses, lesion detectability, and semiautomated delineation methods. These findings support imaging protocols that keep radiation exposure levels as low as reasonably or practically achievable, which are particularly relevant for radiation-sensitive patients (e.g., children, pregnant women).

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