一种新的靶向PD-1的肽：蛋白-蛋白相互作用研究和免疫治疗的意义

IF 4.3 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-04-25 DOI:10.1039/d5cc01198a

Satya Arya, Hari Prasad Timilsina, Siddhartha Thennakoon, Rick Postema, Raunak Jahan, Andrew Michael Reynolds, Xiaohong Tan

{"title":"一种新的靶向PD-1的肽：蛋白-蛋白相互作用研究和免疫治疗的意义","authors":"Satya Arya, Hari Prasad Timilsina, Siddhartha Thennakoon, Rick Postema, Raunak Jahan, Andrew Michael Reynolds, Xiaohong Tan","doi":"10.1039/d5cc01198a","DOIUrl":null,"url":null,"abstract":"Chemical ligand binding to PD-1 is a powerful approach for studying protein-protein interactions and advancing immunotherapy. In this study, we introduce a novel II peptide with strong binding affinity for PD-1. Molecular docking analysis reveals key interactions between the II peptide and PD-1, supporting inhibition ELISA data and indicating that the II peptide overlaps with the PD-1/PD-L1 interaction interface.","PeriodicalId":67,"journal":{"name":"Chemical Communications","volume":"1 1","pages":""},"PeriodicalIF":4.3000,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A Novel Peptide Targeting PD-1: Implications for Protein-Protein Interaction Studies and Immunotherapy\",\"authors\":\"Satya Arya, Hari Prasad Timilsina, Siddhartha Thennakoon, Rick Postema, Raunak Jahan, Andrew Michael Reynolds, Xiaohong Tan\",\"doi\":\"10.1039/d5cc01198a\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Chemical ligand binding to PD-1 is a powerful approach for studying protein-protein interactions and advancing immunotherapy. In this study, we introduce a novel II peptide with strong binding affinity for PD-1. Molecular docking analysis reveals key interactions between the II peptide and PD-1, supporting inhibition ELISA data and indicating that the II peptide overlaps with the PD-1/PD-L1 interaction interface.\",\"PeriodicalId\":67,\"journal\":{\"name\":\"Chemical Communications\",\"volume\":\"1 1\",\"pages\":\"\"},\"PeriodicalIF\":4.3000,\"publicationDate\":\"2025-04-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemical Communications\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1039/d5cc01198a\",\"RegionNum\":2,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemical Communications","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d5cc01198a","RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

化学配体结合PD-1是研究蛋白质相互作用和推进免疫治疗的有力途径。在这项研究中，我们引入了一种对PD-1具有强结合亲和力的新型II肽。分子对接分析揭示了II肽与PD-1之间的关键相互作用，支持抑制ELISA数据，并表明II肽与PD-1/PD-L1相互作用界面重叠。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

A Novel Peptide Targeting PD-1: Implications for Protein-Protein Interaction Studies and Immunotherapy

Chemical ligand binding to PD-1 is a powerful approach for studying protein-protein interactions and advancing immunotherapy. In this study, we introduce a novel II peptide with strong binding affinity for PD-1. Molecular docking analysis reveals key interactions between the II peptide and PD-1, supporting inhibition ELISA data and indicating that the II peptide overlaps with the PD-1/PD-L1 interaction interface.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.