肿瘤微环境芯片和单细胞分析揭示基质-免疫串扰在乳腺癌进展中的协同作用（Sci. 16/2025）

IF 14.3 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Science Pub Date : 2025-04-24 DOI:10.1002/advs.202570119

Kalpana Ravi, Yining Zhang, Lydia Sakala, Twinkle Jina Minette Manoharan, Barbara Pockaj, Joshua LaBaer, Jin G. Park, Mehdi Nikkhah

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引用次数: 0

摘要

这张图片描绘了一个前沿的3D肿瘤芯片模型，它概括了乳房肿瘤微环境，突出了基质、免疫和转移性三阴性乳腺癌细胞之间的相互作用。通过模拟肿瘤-基质-免疫串扰，该模型通过生物信息学分析揭示了癌细胞代谢重编程。这个创新的平台促进了对肿瘤生物学的理解，提供了对细胞适应和潜在治疗靶点的见解。更多细节可以在Mehdi Nikkhah及其同事的2413457号文章中找到。创建与BioRender.com。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Tumor Microenvironment On-A-Chip and Single-Cell Analysis Reveal Synergistic Stromal–Immune Crosstalk on Breast Cancer Progression (Adv. Sci. 16/2025)

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Tumor Microenvironment On-A-Chip and Single-Cell Analysis Reveal Synergistic Stromal–Immune Crosstalk on Breast Cancer Progression (Adv. Sci. 16/2025)

Tumor on-a-Chip

This image depicts a cutting-edge 3D tumor-on-a-chip model that recapitulates the breast tumor microenvironment, highlighting interactions between stromal, immune, and metastatic triplenegative breast cancer cells. By mimicking tumor-stroma-immune crosstalk, this model reveals cancer cell metabolic reprogramming through bioinformatic analysis. This innovative platform advances the understanding of tumor biology, providing insights into cellular adaptations and potential therapeutic targets. More details can be found in article number 2413457 by Mehdi Nikkhah, and co-workers. Create with BioRender.com.

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来源期刊

Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

18.90

自引率

2.60%

发文量

1602

审稿时长

1.9 months

期刊介绍： Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.