一种可注射的多功能纳米清扫器消除心脏线粒体DNA，减少炎症（Adv. Healthcare Mater. 11/2025）

IF 9.6 2区医学 Q1 ENGINEERING, BIOMEDICAL

Advanced Healthcare Materials Pub Date : 2025-04-25 DOI:10.1002/adhm.202570068

Yi-Jing Li, Xiumeng Hua, Yi-Qi Zhao, Han Mo, Shun Liu, Xiao Chen, Zhe Sun, Weiteng Wang, Qian Zhao, Zeyu Cui, Tao An, Jiangping Song

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引用次数: 0

摘要

nanosweeper作为一种清道夫，通过心脏靶向肽的导航到达心肌炎的病灶部位，开始执行线粒体DNA清除的任务。同时，手持STING抑制剂协同抑制STING通路，抑制炎症风暴，改善心肌炎。更多的细节可以在文章2404068中找到，作者是Hua Xiumeng， An Tao， Jiangping Song和同事。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

An Injectable Multifunctional Nanosweeper Eliminates Cardiac Mitochondrial DNA to Reduce Inflammation (Adv. Healthcare Mater. 11/2025)

查看原文本刊更多论文

An Injectable Multifunctional Nanosweeper Eliminates Cardiac Mitochondrial DNA to Reduce Inflammation (Adv. Healthcare Mater. 11/2025)

Myocarditis

Nanosweeper, acting as a scavenger, arrives at the focal site of myocarditis through the navigation of heart-targeted peptides and starts to perform the task of mitochondrial DNA clearance. At the same time, STING inhibitors are held in hand to synergistic inhibit the STING pathway, inhibit the inflammatory storm and improve myocarditis. More details can be found in article 2404068 by Xiumeng Hua, Tao An, Jiangping Song, and co-workers.

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来源期刊

Advanced Healthcare Materials 工程技术-生物材料

CiteScore

14.40

自引率

3.00%

发文量

600

审稿时长

1.8 months

期刊介绍： Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.