Kdm6a和Kdm6b在哺乳动物神经再生调控中的作用（Sci. 16/2025）

IF 14.1 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Science Pub Date : 2025-04-24 DOI:10.1002/advs.202570118

Shu-Guang Yang, Chang-Ping Li, Xue-Wei Wang, Tao Huang, Cheng Qian, Qiao Li, Ling-Rui Zhao, Si-Yu Zhou, Chen-Yun Ding, Rui Nie, Saijilafu, Yu-Cai Hong, Chang-Mei Liu, Feng-Quan Zhou

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引用次数: 0

摘要

哺乳动物神经再生：青光眼主要由视神经损伤引起。Yang Shu-Guang、Li Chang-Ping及其同事有了突破性的发现：删除神经元中的组蛋白去甲基化酶Kdm6a会增加组蛋白甲基化水平。这种变化改变了染色体结构，使其更加密集，并有效地沉默了再生抑制基因的表达。在2405537号文章中描述的这项研究确定了治疗青光眼和其他视网膜损伤的有希望的新靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Roles of Kdm6a and Kdm6b in Regulation of Mammalian Neural Regeneration (Adv. Sci. 16/2025)

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Roles of Kdm6a and Kdm6b in Regulation of Mammalian Neural Regeneration (Adv. Sci. 16/2025)

Mammalian Neural Regeneration

Glaucoma primarily results from damage to the optic nerves. Shu-Guang Yang, Chang-Ping Li, and co-workers have made a groundbreaking discovery: deleting the histone demethylase Kdm6a in neurons increases histone methylation levels. This change alters the chromosome structure, making it more densely packed and effectively silencing the expression of regeneration suppressor genes. This study described in article number 2405537 identifies a promising new target for treating glaucoma and other retinal injuries.

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来源期刊

Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

18.90

自引率

2.60%

发文量

1602

审稿时长

1.9 months

期刊介绍： Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.