{"title":"金属催化烯烃的还原烷基化:从铜到替代催化剂","authors":"Deyuan Meng, Jaesook Yun","doi":"10.1002/bkcs.70016","DOIUrl":null,"url":null,"abstract":"<p>In recent years, transition metal-catalyzed reductive alkylation of alkenes has gained attention due to its ability to circumvent the use of unstable organometallic reagents by generating reactive intermediates in situ from stable precursors with enhanced reaction safety and efficiency. This review provides an overview of recent advancements in copper-catalyzed reductive alkylation of alkenes, with a particular focus on the use of hydrosilanes and diborons as stoichiometric reducing agents. Key topics include mechanistic insights, strategies for controlling regio- and stereoselectivity in both intra- and intermolecular alkylation reactions, and innovative catalyst designs for selective product synthesis. Emerging trends such as radical-mediated transformations and contributions from alternative first-row transition metals including nickel and iron are also discussed.</p>","PeriodicalId":54252,"journal":{"name":"Bulletin of the Korean Chemical Society","volume":"46 4","pages":"413-421"},"PeriodicalIF":1.7000,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Metal-catalyzed reductive alkylation of alkenes: From copper to alternative catalysts\",\"authors\":\"Deyuan Meng, Jaesook Yun\",\"doi\":\"10.1002/bkcs.70016\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>In recent years, transition metal-catalyzed reductive alkylation of alkenes has gained attention due to its ability to circumvent the use of unstable organometallic reagents by generating reactive intermediates in situ from stable precursors with enhanced reaction safety and efficiency. This review provides an overview of recent advancements in copper-catalyzed reductive alkylation of alkenes, with a particular focus on the use of hydrosilanes and diborons as stoichiometric reducing agents. Key topics include mechanistic insights, strategies for controlling regio- and stereoselectivity in both intra- and intermolecular alkylation reactions, and innovative catalyst designs for selective product synthesis. Emerging trends such as radical-mediated transformations and contributions from alternative first-row transition metals including nickel and iron are also discussed.</p>\",\"PeriodicalId\":54252,\"journal\":{\"name\":\"Bulletin of the Korean Chemical Society\",\"volume\":\"46 4\",\"pages\":\"413-421\"},\"PeriodicalIF\":1.7000,\"publicationDate\":\"2025-04-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bulletin of the Korean Chemical Society\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/bkcs.70016\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bulletin of the Korean Chemical Society","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/bkcs.70016","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Metal-catalyzed reductive alkylation of alkenes: From copper to alternative catalysts
In recent years, transition metal-catalyzed reductive alkylation of alkenes has gained attention due to its ability to circumvent the use of unstable organometallic reagents by generating reactive intermediates in situ from stable precursors with enhanced reaction safety and efficiency. This review provides an overview of recent advancements in copper-catalyzed reductive alkylation of alkenes, with a particular focus on the use of hydrosilanes and diborons as stoichiometric reducing agents. Key topics include mechanistic insights, strategies for controlling regio- and stereoselectivity in both intra- and intermolecular alkylation reactions, and innovative catalyst designs for selective product synthesis. Emerging trends such as radical-mediated transformations and contributions from alternative first-row transition metals including nickel and iron are also discussed.
期刊介绍:
The Bulletin of the Korean Chemical Society is an official research journal of the Korean Chemical Society. It was founded in 1980 and reaches out to the chemical community worldwide. It is strictly peer-reviewed and welcomes Accounts, Communications, Articles, and Notes written in English. The scope of the journal covers all major areas of chemistry: analytical chemistry, electrochemistry, industrial chemistry, inorganic chemistry, life-science chemistry, macromolecular chemistry, organic synthesis, non-synthetic organic chemistry, physical chemistry, and materials chemistry.