金属催化烯烃的还原烷基化:从铜到替代催化剂

IF 1.7 4区 化学
Deyuan Meng, Jaesook Yun
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引用次数: 0

摘要

近年来,过渡金属催化烯烃的还原性烷基化反应受到了人们的关注,因为它可以避免使用不稳定的有机金属试剂,从稳定的前体原位生成反应中间体,提高了反应的安全性和效率。本文综述了近年来铜催化烯烃还原烷基化的研究进展,重点介绍了氢硅烷和二硼作为化学计量还原剂的应用。关键主题包括机制见解,控制区域和分子间烷基化反应的立体选择性的策略,以及选择性产物合成的创新催化剂设计。新兴的趋势,如自由基介导的转变和贡献的替代第一排过渡金属,包括镍和铁也进行了讨论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Metal-catalyzed reductive alkylation of alkenes: From copper to alternative catalysts

In recent years, transition metal-catalyzed reductive alkylation of alkenes has gained attention due to its ability to circumvent the use of unstable organometallic reagents by generating reactive intermediates in situ from stable precursors with enhanced reaction safety and efficiency. This review provides an overview of recent advancements in copper-catalyzed reductive alkylation of alkenes, with a particular focus on the use of hydrosilanes and diborons as stoichiometric reducing agents. Key topics include mechanistic insights, strategies for controlling regio- and stereoselectivity in both intra- and intermolecular alkylation reactions, and innovative catalyst designs for selective product synthesis. Emerging trends such as radical-mediated transformations and contributions from alternative first-row transition metals including nickel and iron are also discussed.

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来源期刊
Bulletin of the Korean Chemical Society
Bulletin of the Korean Chemical Society Chemistry-General Chemistry
自引率
23.50%
发文量
182
期刊介绍: The Bulletin of the Korean Chemical Society is an official research journal of the Korean Chemical Society. It was founded in 1980 and reaches out to the chemical community worldwide. It is strictly peer-reviewed and welcomes Accounts, Communications, Articles, and Notes written in English. The scope of the journal covers all major areas of chemistry: analytical chemistry, electrochemistry, industrial chemistry, inorganic chemistry, life-science chemistry, macromolecular chemistry, organic synthesis, non-synthetic organic chemistry, physical chemistry, and materials chemistry.
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