利用纳升基质滑片快速高通量发现天然产物中具有抗菌活性的分子（Small Methods 4/2025）

IF 10.7 2区材料科学 Q1 CHEMISTRY, PHYSICAL

Small Methods Pub Date : 2025-04-24 DOI:10.1002/smtd.202570025

Qi Wang, Mengru Wang, Weiyuan Lyu, Xiang Li, Lei Xu, Yuyao Qin, Yan'an Ren, Zixin Deng, Meifeng Tao, Weilie Xiao, Feng Shen

{"title":"利用纳升基质滑片快速高通量发现天然产物中具有抗菌活性的分子（Small Methods 4/2025）","authors":"Qi Wang, Mengru Wang, Weiyuan Lyu, Xiang Li, Lei Xu, Yuyao Qin, Yan'an Ren, Zixin Deng, Meifeng Tao, Weilie Xiao, Feng Shen","doi":"10.1002/smtd.202570025","DOIUrl":null,"url":null,"abstract":"Novel AntibioticsThe nm-SlipChip creates a screening matrix using nanoliter droplets to test 100 drug candidate-bacterium combinations, evaluating antibiotic effectiveness based on phenotypic changes in microorganisms. It reduces sample consumption by more than 5000-fold and shortens detection time to approximately three hours. Using this nm-SlipChip, we identified two new clerodane diterpenes from Callicarpa integerrima that inhibit MRSA. More in article number 2402045, Tao, Xiao, Shen and co-workers.\n\n <figure>\n <div><picture>\n <source></source></picture>\n </div>\n </figure>","PeriodicalId":229,"journal":{"name":"Small Methods","volume":"9 4","pages":""},"PeriodicalIF":10.7000,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/smtd.202570025","citationCount":"0","resultStr":"{\"title\":\"Rapid High-Throughput Discovery of Molecules With Antimicrobial Activity From Natural Products Enabled by a Nanoliter Matrix SlipChip (Small Methods 4/2025)\",\"authors\":\"Qi Wang, Mengru Wang, Weiyuan Lyu, Xiang Li, Lei Xu, Yuyao Qin, Yan'an Ren, Zixin Deng, Meifeng Tao, Weilie Xiao, Feng Shen\",\"doi\":\"10.1002/smtd.202570025\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Novel AntibioticsThe nm-SlipChip creates a screening matrix using nanoliter droplets to test 100 drug candidate-bacterium combinations, evaluating antibiotic effectiveness based on phenotypic changes in microorganisms. It reduces sample consumption by more than 5000-fold and shortens detection time to approximately three hours. Using this nm-SlipChip, we identified two new clerodane diterpenes from Callicarpa integerrima that inhibit MRSA. More in article number 2402045, Tao, Xiao, Shen and co-workers.\\n\\n <figure>\\n <div><picture>\\n <source></source></picture>\\n </div>\\n </figure>\",\"PeriodicalId\":229,\"journal\":{\"name\":\"Small Methods\",\"volume\":\"9 4\",\"pages\":\"\"},\"PeriodicalIF\":10.7000,\"publicationDate\":\"2025-04-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1002/smtd.202570025\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Small Methods\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1002/smtd.202570025\",\"RegionNum\":2,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, PHYSICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Small Methods","FirstCategoryId":"88","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/smtd.202570025","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}

引用次数: 0

摘要

新型抗生素纳米滑片使用纳米液滴创建筛选基质，测试100种候选药物-细菌组合，根据微生物的表型变化评估抗生素的有效性。它将样品消耗减少了5000倍以上，并将检测时间缩短至约3小时。利用nm-SlipChip技术，我们鉴定出了两种新的可抑制MRSA的氯烷二萜。在文章编号2402045中，陶，肖，沈和同事。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Rapid High-Throughput Discovery of Molecules With Antimicrobial Activity From Natural Products Enabled by a Nanoliter Matrix SlipChip (Small Methods 4/2025)

查看原文本刊更多论文

Rapid High-Throughput Discovery of Molecules With Antimicrobial Activity From Natural Products Enabled by a Nanoliter Matrix SlipChip (Small Methods 4/2025)

Novel Antibiotics

The nm-SlipChip creates a screening matrix using nanoliter droplets to test 100 drug candidate-bacterium combinations, evaluating antibiotic effectiveness based on phenotypic changes in microorganisms. It reduces sample consumption by more than 5000-fold and shortens detection time to approximately three hours. Using this nm-SlipChip, we identified two new clerodane diterpenes from Callicarpa integerrima that inhibit MRSA. More in article number 2402045, Tao, Xiao, Shen and co-workers.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Small Methods Materials Science-General Materials Science

CiteScore

17.40

自引率

1.60%

发文量

347

期刊介绍： Small Methods is a multidisciplinary journal that publishes groundbreaking research on methods relevant to nano- and microscale research. It welcomes contributions from the fields of materials science, biomedical science, chemistry, and physics, showcasing the latest advancements in experimental techniques. With a notable 2022 Impact Factor of 12.4 (Journal Citation Reports, Clarivate Analytics, 2023), Small Methods is recognized for its significant impact on the scientific community. The online ISSN for Small Methods is 2366-9608.