隐球菌性眼内炎合并恶性肿瘤1例报告并文献复习

IF 1.6 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical Mycology Case Reports Pub Date : 2025-04-23 DOI:10.1016/j.mmcr.2025.100703

Kamonchanok Phaopraphat, Rujipas Sirijatuphat

{"title":"隐球菌性眼内炎合并恶性肿瘤1例报告并文献复习","authors":"Kamonchanok Phaopraphat, Rujipas Sirijatuphat","doi":"10.1016/j.mmcr.2025.100703","DOIUrl":null,"url":null,"abstract":"<div><div>Cryptococcal endophthalmitis is a rare manifestation of cryptococcal infection, typically occurring in immunocompromised patients. In this case report, we present a 50-year-old female with advanced-stage lung cancer with multiple metastases presenting with blurred vision for 10 days. A diagnostic pars plana vitrectomy revealed <em>Cryptococcus neoformans</em> in the vitreous. She was treated with systemic amphotericin B and flucytosine, followed by fluconazole for consolidation and maintenance, along with intravitreal amphotericin B and voriconazole injections. Her visual acuity improved from counting fingers at 2 feet to 3/60, with a pinhole correction of 6/18 after 10 months of treatment.</div></div>","PeriodicalId":51724,"journal":{"name":"Medical Mycology Case Reports","volume":"48 ","pages":"Article 100703"},"PeriodicalIF":1.6000,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Cryptococcal endophthalmitis in a patient with malignancy: A case report and literature review\",\"authors\":\"Kamonchanok Phaopraphat, Rujipas Sirijatuphat\",\"doi\":\"10.1016/j.mmcr.2025.100703\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Cryptococcal endophthalmitis is a rare manifestation of cryptococcal infection, typically occurring in immunocompromised patients. In this case report, we present a 50-year-old female with advanced-stage lung cancer with multiple metastases presenting with blurred vision for 10 days. A diagnostic pars plana vitrectomy revealed <em>Cryptococcus neoformans</em> in the vitreous. She was treated with systemic amphotericin B and flucytosine, followed by fluconazole for consolidation and maintenance, along with intravitreal amphotericin B and voriconazole injections. Her visual acuity improved from counting fingers at 2 feet to 3/60, with a pinhole correction of 6/18 after 10 months of treatment.</div></div>\",\"PeriodicalId\":51724,\"journal\":{\"name\":\"Medical Mycology Case Reports\",\"volume\":\"48 \",\"pages\":\"Article 100703\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2025-04-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Medical Mycology Case Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2211753925000120\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, RESEARCH & EXPERIMENTAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Medical Mycology Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2211753925000120","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, RESEARCH & EXPERIMENTAL","Score":null,"Total":0}

引用次数: 0

摘要

隐球菌性眼内炎是一种罕见的隐球菌感染的表现，通常发生在免疫功能低下的患者。在这个病例报告中，我们报告了一位50岁的晚期肺癌女性，伴有多发转移，表现为视力模糊10天。诊断性玻璃体切除发现玻璃体内有新型隐球菌。患者全身性给予两性霉素B和氟胞嘧啶治疗，随后给予氟康唑巩固和维持，同时玻璃体内注射两性霉素B和伏立康唑。经过10个月的治疗，她的视力从2英尺数到3/60，针孔矫正到6/18。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Cryptococcal endophthalmitis in a patient with malignancy: A case report and literature review

Cryptococcal endophthalmitis is a rare manifestation of cryptococcal infection, typically occurring in immunocompromised patients. In this case report, we present a 50-year-old female with advanced-stage lung cancer with multiple metastases presenting with blurred vision for 10 days. A diagnostic pars plana vitrectomy revealed Cryptococcus neoformans in the vitreous. She was treated with systemic amphotericin B and flucytosine, followed by fluconazole for consolidation and maintenance, along with intravitreal amphotericin B and voriconazole injections. Her visual acuity improved from counting fingers at 2 feet to 3/60, with a pinhole correction of 6/18 after 10 months of treatment.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Medical Mycology Case Reports MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

4.00

自引率

0.00%

发文量

审稿时长

47 days