D-π-A型七甲基发色团的合成、性质及其在PTT/PDT协同肿瘤治疗中的应用

IF 2.7 4区材料科学 Q3 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materials Letters Pub Date : 2025-04-22 DOI:10.1016/j.matlet.2025.138614

Lu Li , Jiagen Li , Xiaoyan Zhang , Jiexue Wang , Lijuan Zhao , Jun Liu , Guowei Deng

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引用次数: 0

摘要

开发优良的光敏剂用于光热和光动力治疗具有重要意义。本文以苯并[cd]吲哚啉、四烯和三氰呋喃衍生物（TCF）分别为电子给体、电子桥和电子受体，设计、合成了一种新型D-π-A型七甲基发色团（ILC），并对其作为潜在光敏剂进行了系统研究。ILC在近红外区域具有较强的吸光度，在808 nm （0.5 W cm−2）激光照射下，ILC NPs表现出明显的活性氧（ROS）生成能力、良好的光热转换性能（808 nm光热转换效率为76.6%）和优异的光热稳定性。最后，在4 T1肿瘤异种移植模式下研究了成像和PTT/PDT协同治疗，结果表明ILC NPs具有良好的体内成像质量和治疗效果。

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Synthesis and properties of a D-π-A type heptamethine chromophore and its application in PTT/PDT synergistic cancer therapy

Developing excellent photosensitizer for photothermal and photodynamic therapy is of great significance. In this work, a novel D-π-A type heptamethine chromophore (ILC) utilizing benz[cd]indoline, tetra-ene and tricyanofuran derivative (TCF) as the electron donor, electron bridge and electron acceptor respectively was designed, synthesized and systematically studied as the potential photosensitizer. ILC possesses strong absorbance in the near-infrared region, and under the irradiation by 808 nm (0.5 W cm⁻²) laser, ILC NPs exhibited obvious reactive oxygen specials (ROS) generation ability, good photothermal conversation performance (photothermal conversation efficiencies were calculated to 76.6 % at 808 nm) and excellent photothermal stability. Finally, the imaging and PTT/PDT synergistic therapy were investigated in a 4 T1 tumor xenograft mode, and the results indicated that ILC NPs possesses good imaging quality and therapy efficacy in vivo.

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来源期刊

Materials Letters 工程技术-材料科学：综合

CiteScore

5.60

自引率

3.30%

发文量

1948

审稿时长

50 days

期刊介绍： Materials Letters has an open access mirror journal Materials Letters: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Materials Letters is dedicated to publishing novel, cutting edge reports of broad interest to the materials community. The journal provides a forum for materials scientists and engineers, physicists, and chemists to rapidly communicate on the most important topics in the field of materials. Contributions include, but are not limited to, a variety of topics such as: • Materials - Metals and alloys, amorphous solids, ceramics, composites, polymers, semiconductors • Applications - Structural, opto-electronic, magnetic, medical, MEMS, sensors, smart • Characterization - Analytical, microscopy, scanning probes, nanoscopic, optical, electrical, magnetic, acoustic, spectroscopic, diffraction • Novel Materials - Micro and nanostructures (nanowires, nanotubes, nanoparticles), nanocomposites, thin films, superlattices, quantum dots. • Processing - Crystal growth, thin film processing, sol-gel processing, mechanical processing, assembly, nanocrystalline processing. • Properties - Mechanical, magnetic, optical, electrical, ferroelectric, thermal, interfacial, transport, thermodynamic • Synthesis - Quenching, solid state, solidification, solution synthesis, vapor deposition, high pressure, explosive