灵芝三萜抗炎症及肾纤维化作用

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-04-14 DOI:10.1016/j.fitote.2025.106543

Jian-Biao Zhang , Sheng-Hong Li , Zhi-Yuan Li , Yong-Ming Yan , Yong-Xian Cheng

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引用次数: 0

摘要

从耳蜗灵芝中分离到7个新的三萜类化合物fornicatins N−T（1-7）。它们的结构包括绝对构型通过1D和2D核磁共振波谱、计算方法和hresms确定。化合物1、3和6的结构也通过x射线晶体学分析进行了表征。特别是化合物1具有6/4/6/5四环三萜骨架。采用Western blot和CCK-8检测化合物1 ~ 7的生物活性。发现化合物6具有显著的抗肾纤维化活性，化合物3、4、6具有显著的抗炎活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Triterpenoids from Ganoderma cochlear against inflammation and renal fibrosis

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Triterpenoids from Ganoderma cochlear against inflammation and renal fibrosis

Seven new triterpenoids, fornicatins N − T (1–7), were isolated from Ganoderma cochlear. Their structures including absolute configurations were determined by 1D and 2D nuclear magnetic resonance (NMR) spectroscopy, computational methods, and HRESIMS. The structures of compounds 1, 3, and 6 were also characterized by X-ray crystallographic analysis. In particular, compound 1 features a 6/4/6/5 tetracyclic triterpenoid skeleton. The biological activities of compounds 1–7 were evaluated using Western blot and CCK-8 assays. It was found that compound 6 exhibited significant anti-renal fibrosis activity, while compounds 3, 4, and 6 demonstrated notable anti-inflammatory activity.

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.