芽孢杆菌属益生菌的次生代谢物作为多药耐药病原体的潜在治疗方法：综述

IF 5.8 Q1 MICROBIOLOGY

Current Research in Microbial Sciences Pub Date : 2025-01-01 DOI:10.1016/j.crmicr.2025.100392

George Michael Nicolas

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引用次数: 0

摘要

抗生素的发现是一项重大的医学突破，挽救了数百万人的生命。然而，抗生素的广泛误用和过度使用导致了抗菌素耐药性的发展。芽孢杆菌属的孢子形成益生菌通过产生菌株特有的生物活性次生代谢物而被广泛用作抗菌剂。本文综述了芽孢杆菌次级代谢物群的广谱抗菌活性及其已报道的作用机制，强调了开发新型抗菌药物的紧迫性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Secondary Metabolites from Bacillus spp. probiotics as potential treatments for multidrug-resistant pathogens: A comprehensive review

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Secondary Metabolites from Bacillus spp. probiotics as potential treatments for multidrug-resistant pathogens: A comprehensive review

The discovery of antibiotics is a significant medical breakthrough, saving millions of lives. However, the widespread misuse and overuse of antibiotics led to the development of antimicrobial resistance. Spore-forming probiotics from Bacillus spp. show great interest as antimicrobial agents through the production of strain-specific bioactive secondary metabolites. This review summarizes the broad-spectrum antimicrobial activities of Bacillus spp. secondary metabolite groups and their reported mechanisms of action, underscoring the urgency in developing novel antimicrobial drugs.

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来源期刊

Current Research in Microbial Sciences Immunology and Microbiology-Immunology and Microbiology (miscellaneous)

CiteScore

7.90

自引率

0.00%

发文量

审稿时长

66 days