磷脂酰肌醇4-phosphate;具有多重人格的小脂质

IF 3.9 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochimica et biophysica acta. Molecular and cell biology of lipids Pub Date : 2025-04-20 DOI:10.1016/j.bbalip.2025.159615

Tamas Balla

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引用次数: 0

摘要

磷脂酰肌醇（PI）的磷酸化产物Diphosphoinositide （DPI）和triphosphoinositide （TPI）在很久以前就被发现了，并且基于它们快速的32p -磷酸标记发现它们具有很高的周转率。PI激酶的活性负责它们的生产随后被确定并发现与不同的细胞器膜，包括质膜相关。这些活性随后与一组特定的细胞表面受体连接，这些受体激活磷脂酶C酶水解PI，并使用钙或cGMP作为第二信使。整整50年前，罗伯特•米歇尔（Robert michel）在一篇影响深远的BBA评论中提出了这一富有远见的概念。PI - 4-磷酸（PI4P）（该术语已取代DPI）的酶学和功能多样性从此经历了无法预见的扩展。在这篇评论中，我将尝试用一些历史反思来重新审视这一扩展，以庆祝米歇尔评论发表50周年。

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Phosphatidylinositol 4-phosphate; A minor lipid with multiple personalities

Phosphorylated products of phosphatidylinositol (PI), named Diphosphoinositide (DPI) and triphosphoinositide (TPI) were identified long time ago and found to exhibit high turnover rates based on their rapid ³²P-phosphate labeling. The PI kinase activities that were responsible for their production were subsequently identified and found to be associated with different organelle membranes, including the plasma membrane. These activities were then linked with a certain group of cell surface receptors that activated phospholipase C enzymes to hydrolyze PI and used calcium or cGMP as a second messenger. This visionary concept was introduced in the seminal BBA review written by Robert Michell, exactly 50 years ago. The enzymology and functional diversity of PI 4-phosphate (PI4P) (the term that has replaced DPI) has since underwent an expansion that could not have been foreseen. In this review I will attempt to revisit this expansion with some historical reflections celebrating the 50th anniversary of the Michell review.

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来源期刊

Biochimica et biophysica acta. Molecular and cell biology of lipids 生物-生化与分子生物学

CiteScore

11.00

自引率

2.10%

发文量

109

审稿时长

53 days

期刊介绍： BBA Molecular and Cell Biology of Lipids publishes papers on original research dealing with novel aspects of molecular genetics related to the lipidome, the biosynthesis of lipids, the role of lipids in cells and whole organisms, the regulation of lipid metabolism and function, and lipidomics in all organisms. Manuscripts should significantly advance the understanding of the molecular mechanisms underlying biological processes in which lipids are involved. Papers detailing novel methodology must report significant biochemical, molecular, or functional insight in the area of lipids.