与生产18f标记的放射性药物有关的富18O水中18O含量的密度测量

IF 1.6 3区工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Applied Radiation and Isotopes Pub Date : 2025-04-16 DOI:10.1016/j.apradiso.2025.111848

Paula Y. Steinberg , Franco T. Bietti , Naila Gomez , Guillermo Casale , Horacio R. Corti

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引用次数: 0

摘要

在293.15至313.15 K的温度范围内，用振动管密度计测量了普通水和18O富集水的混合物的密度。从18O富水区密度数据的误差分析(原子% 18O >；95)我们得出结论，密度测量的精度为±0.00002 g cm−3，提供了一种简单、精确和低成本的方法来确定用于生产放射性药物的再生重氧水的18O富集程度，例如用于正电子发射断层扫描（PET）扫描的[18F]氟-2-脱氧-d -葡萄糖。

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Densitometric measurement of 18O content of 18O-enriched water in relation to the production of 18F-labelled radiopharmaceuticals

The densities of mixtures of ordinary water and ¹⁸O enriched water have been measured all over the range of compositions, at temperatures between 293.15 and 313.15 K, using a vibrating-tube densitometer. From the error analysis of the density data in the ¹⁸O enriched water region (atom % ¹⁸O > 95) we concluded that densitometry measurements with an accuracy of ±0.00002 g cm⁻³, provide a simple, precise and low-cost method to determine the ¹⁸O enrichment degree of recycled heavy oxygen water used to generate radiopharmaceuticals, such as [¹⁸F]fluoro-2-deoxy-D-glucose for the Positron-Emission Tomography (PET) scanning.

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来源期刊

Applied Radiation and Isotopes 工程技术-核科学技术

CiteScore

3.00

自引率

12.50%

发文量

406

审稿时长

13.5 months

期刊介绍： Applied Radiation and Isotopes provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and peaceful application of nuclear, radiation and radionuclide techniques in chemistry, physics, biochemistry, biology, medicine, security, engineering and in the earth, planetary and environmental sciences, all including dosimetry. Nuclear techniques are defined in the broadest sense and both experimental and theoretical papers are welcome. They include the development and use of α- and β-particles, X-rays and γ-rays, neutrons and other nuclear particles and radiations from all sources, including radionuclides, synchrotron sources, cyclotrons and reactors and from the natural environment. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. Papers dealing with radiation processing, i.e., where radiation is used to bring about a biological, chemical or physical change in a material, should be directed to our sister journal Radiation Physics and Chemistry.