{"title":"碳量子点修饰二硫化钼协同光热和光动力治疗细菌感染","authors":"Yayu Chen, Pengcheng Huang, Wenting Hong, Wanqing Xu, Xiaoping Chen, Shuxian Li, Chaojin Liu, Yuansheng Wang, Xiaoyan Zhang*, Yuqiong Wu* and Fangchuan Chen*, ","doi":"10.1021/acsanm.5c0149110.1021/acsanm.5c01491","DOIUrl":null,"url":null,"abstract":"<p >Oral and maxillofacial infections are primarily caused by pyogenic bacterial infections, with common pathogens including <i>Staphylococcus aureus</i> and <i>Escherichia coli</i>. In this study, we developed a nonantibiotic antibacterial material, carbon quantum dots (CQDs) modified molybdenum disulfide (MoS<sub>2</sub>), through a well-designed fabrication process. CQDs were used as highly efficient cocatalysts to enhance the near-infrared absorption capacity of the composite. Under near-infrared light (NIR) irradiation (1.5 W/cm<sup>2</sup> for 5 min), the 18.75% CQDs/MoS<sub>2</sub> composite, with CQDs concentration reaching 18.75%, exhibited complete antibacterial activity, demonstrating 100% efficacy against both <i>S. aureus</i> and <i>E. coli</i>. In addition, under NIR irradiation, the obtained CQDs/MoS<sub>2</sub> displayed remarkable wound healing performance, as well as antioxidative and anti-inflammatory capabilities. The improved antibacterial and wound healing performance were attributed to the synergistic effects of hyperthermia-mediated photothermal therapy (PTT) and reactive oxygen species (ROS)-mediated photodynamic therapy (PDT). This study offers a promising approach for managing maxillofacial wound infections.</p>","PeriodicalId":6,"journal":{"name":"ACS Applied Nano Materials","volume":"8 16","pages":"8499–8510 8499–8510"},"PeriodicalIF":5.3000,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Synergistic Photothermal and Photodynamic Therapy against Bacterial Infections Using Carbon Quantum Dots Modified Molybdenum Disulfide\",\"authors\":\"Yayu Chen, Pengcheng Huang, Wenting Hong, Wanqing Xu, Xiaoping Chen, Shuxian Li, Chaojin Liu, Yuansheng Wang, Xiaoyan Zhang*, Yuqiong Wu* and Fangchuan Chen*, \",\"doi\":\"10.1021/acsanm.5c0149110.1021/acsanm.5c01491\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Oral and maxillofacial infections are primarily caused by pyogenic bacterial infections, with common pathogens including <i>Staphylococcus aureus</i> and <i>Escherichia coli</i>. In this study, we developed a nonantibiotic antibacterial material, carbon quantum dots (CQDs) modified molybdenum disulfide (MoS<sub>2</sub>), through a well-designed fabrication process. CQDs were used as highly efficient cocatalysts to enhance the near-infrared absorption capacity of the composite. Under near-infrared light (NIR) irradiation (1.5 W/cm<sup>2</sup> for 5 min), the 18.75% CQDs/MoS<sub>2</sub> composite, with CQDs concentration reaching 18.75%, exhibited complete antibacterial activity, demonstrating 100% efficacy against both <i>S. aureus</i> and <i>E. coli</i>. In addition, under NIR irradiation, the obtained CQDs/MoS<sub>2</sub> displayed remarkable wound healing performance, as well as antioxidative and anti-inflammatory capabilities. The improved antibacterial and wound healing performance were attributed to the synergistic effects of hyperthermia-mediated photothermal therapy (PTT) and reactive oxygen species (ROS)-mediated photodynamic therapy (PDT). This study offers a promising approach for managing maxillofacial wound infections.</p>\",\"PeriodicalId\":6,\"journal\":{\"name\":\"ACS Applied Nano Materials\",\"volume\":\"8 16\",\"pages\":\"8499–8510 8499–8510\"},\"PeriodicalIF\":5.3000,\"publicationDate\":\"2025-04-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"ACS Applied Nano Materials\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://pubs.acs.org/doi/10.1021/acsanm.5c01491\",\"RegionNum\":2,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"ACS Applied Nano Materials","FirstCategoryId":"88","ListUrlMain":"https://pubs.acs.org/doi/10.1021/acsanm.5c01491","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
Synergistic Photothermal and Photodynamic Therapy against Bacterial Infections Using Carbon Quantum Dots Modified Molybdenum Disulfide
Oral and maxillofacial infections are primarily caused by pyogenic bacterial infections, with common pathogens including Staphylococcus aureus and Escherichia coli. In this study, we developed a nonantibiotic antibacterial material, carbon quantum dots (CQDs) modified molybdenum disulfide (MoS2), through a well-designed fabrication process. CQDs were used as highly efficient cocatalysts to enhance the near-infrared absorption capacity of the composite. Under near-infrared light (NIR) irradiation (1.5 W/cm2 for 5 min), the 18.75% CQDs/MoS2 composite, with CQDs concentration reaching 18.75%, exhibited complete antibacterial activity, demonstrating 100% efficacy against both S. aureus and E. coli. In addition, under NIR irradiation, the obtained CQDs/MoS2 displayed remarkable wound healing performance, as well as antioxidative and anti-inflammatory capabilities. The improved antibacterial and wound healing performance were attributed to the synergistic effects of hyperthermia-mediated photothermal therapy (PTT) and reactive oxygen species (ROS)-mediated photodynamic therapy (PDT). This study offers a promising approach for managing maxillofacial wound infections.
期刊介绍：
ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.
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