小鼠细胞内源性超氧化物歧化酶和过氧化氢酶活性与辐射抗性。

International journal of radiation biology and related studies in physics, chemistry, and medicine Pub Date : 1988-02-01 DOI:10.1080/09553008814550631

C A Davy, Z Tesfay, J Jones, C McCarthy, S Ostrand-Rosenberg, R C Rosenberg

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引用次数: 2

摘要

用11种小鼠细胞系研究了内源性超氧化物歧化酶和过氧化氢酶水平与辐射抑制细胞增殖的关系。这些小鼠细胞系对辐射的抵抗力相差超过25倍。外推数(EN)、准阈值剂量(Dq)和DO测量的细胞质cuzn -超氧化物歧化酶或过氧化氢酶水平与辐射抗性之间没有相关性。没有细胞系检测到细胞质锰超氧化物歧化酶。测定了小鼠cuzn -超氧化物歧化酶的氰化钾表观Ki值(Ki = 6.5 μ mol dm-3)。

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Endogenous superoxide dismutase and catalase activities and radiation resistance in mouse cell lines.

The relationship between the endogenous cytoplasmic levels of the enzymes superoxide dismutase and catalase and the inhibition of cell proliferation by radiation has been studied in 11 mouse cell lines. The resistance of these mouse cell lines to radiation was found to vary by over 25-fold. No correlation was found between the cytoplasmic level of CuZn-superoxide dismutase or catalase and the resistance to radiation as measured by extrapolation number (EN), quasi-threshold dose (Dq), or DO. None of the cell lines had detectable cytoplasmic Mn-superoxide dismutase. The apparent Ki of potassium cyanide for mouse CuZn-superoxide dismutase was determined (Ki = 6.5 mumol dm-3).

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International journal of radiation biology and related studies in physics, chemistry, and medicine

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