Sana S. Shaikh, Supriya M. Kale, Navjeet K. Lotey, Manish S. Hate, Ramesh S. Chaughule
{"title":"金叶柑橘生物合成纳米氧化锌的抗菌活性研究单果皮抗尿路致病性临床分离株的体外研究","authors":"Sana S. Shaikh, Supriya M. Kale, Navjeet K. Lotey, Manish S. Hate, Ramesh S. Chaughule","doi":"10.1007/s13204-025-03089-8","DOIUrl":null,"url":null,"abstract":"<div><p>This study reports the development of zinc oxide nanoparticles (ZnO NPs) through an eco-friendly, microwave-assisted method using <i>Citrus</i> × <i>aurantiifolia</i> (Christm.) Swingle fruit peel extract as a sustainable resource. Analysis of the produced ZnO NPs verified their spherical shape and hexagonal wurtzite crystal structure. Tests for biocompatibility demonstrated low toxicity to cells from mammals, indicating their potential safe use in biomedical applications. Evaluation of antibacterial properties revealed substantial inhibition of bacterial growth in uropathogenic strains, with minimum inhibitory concentrations (MICs) determined as 7.5 µg/mL for <i>Acinetobacter</i> sp., <i>Enterobacter</i> sp., and <i>Klebsiella pneumoniae</i>; 10 µg/mL for <i>Proteus mirabilis</i>; and 12.5 µg/mL for <i>Escherichia coli</i>. These results underscore the potential of ZnO NPs as effective antimicrobial agents, offering promising applications in combating urinary tract infections (UTIs) and addressing the critical issue of antimicrobial resistance.</p></div>","PeriodicalId":471,"journal":{"name":"Applied Nanoscience","volume":"15 3","pages":""},"PeriodicalIF":3.6740,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Antibacterial activity of biosynthesized nano-zinc oxide from Citrus × aurantiifolia (christm.) Swingle fruit peel against uropathogenic clinical isolates: an in vitro study\",\"authors\":\"Sana S. Shaikh, Supriya M. Kale, Navjeet K. Lotey, Manish S. Hate, Ramesh S. Chaughule\",\"doi\":\"10.1007/s13204-025-03089-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>This study reports the development of zinc oxide nanoparticles (ZnO NPs) through an eco-friendly, microwave-assisted method using <i>Citrus</i> × <i>aurantiifolia</i> (Christm.) Swingle fruit peel extract as a sustainable resource. Analysis of the produced ZnO NPs verified their spherical shape and hexagonal wurtzite crystal structure. Tests for biocompatibility demonstrated low toxicity to cells from mammals, indicating their potential safe use in biomedical applications. Evaluation of antibacterial properties revealed substantial inhibition of bacterial growth in uropathogenic strains, with minimum inhibitory concentrations (MICs) determined as 7.5 µg/mL for <i>Acinetobacter</i> sp., <i>Enterobacter</i> sp., and <i>Klebsiella pneumoniae</i>; 10 µg/mL for <i>Proteus mirabilis</i>; and 12.5 µg/mL for <i>Escherichia coli</i>. These results underscore the potential of ZnO NPs as effective antimicrobial agents, offering promising applications in combating urinary tract infections (UTIs) and addressing the critical issue of antimicrobial resistance.</p></div>\",\"PeriodicalId\":471,\"journal\":{\"name\":\"Applied Nanoscience\",\"volume\":\"15 3\",\"pages\":\"\"},\"PeriodicalIF\":3.6740,\"publicationDate\":\"2025-04-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Applied Nanoscience\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s13204-025-03089-8\",\"RegionNum\":4,\"RegionCategory\":\"工程技术\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"Engineering\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Applied Nanoscience","FirstCategoryId":"5","ListUrlMain":"https://link.springer.com/article/10.1007/s13204-025-03089-8","RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"Engineering","Score":null,"Total":0}
Antibacterial activity of biosynthesized nano-zinc oxide from Citrus × aurantiifolia (christm.) Swingle fruit peel against uropathogenic clinical isolates: an in vitro study
This study reports the development of zinc oxide nanoparticles (ZnO NPs) through an eco-friendly, microwave-assisted method using Citrus × aurantiifolia (Christm.) Swingle fruit peel extract as a sustainable resource. Analysis of the produced ZnO NPs verified their spherical shape and hexagonal wurtzite crystal structure. Tests for biocompatibility demonstrated low toxicity to cells from mammals, indicating their potential safe use in biomedical applications. Evaluation of antibacterial properties revealed substantial inhibition of bacterial growth in uropathogenic strains, with minimum inhibitory concentrations (MICs) determined as 7.5 µg/mL for Acinetobacter sp., Enterobacter sp., and Klebsiella pneumoniae; 10 µg/mL for Proteus mirabilis; and 12.5 µg/mL for Escherichia coli. These results underscore the potential of ZnO NPs as effective antimicrobial agents, offering promising applications in combating urinary tract infections (UTIs) and addressing the critical issue of antimicrobial resistance.
期刊介绍：
Applied Nanoscience is a hybrid journal that publishes original articles about state of the art nanoscience and the application of emerging nanotechnologies to areas fundamental to building technologically advanced and sustainable civilization, including areas as diverse as water science, advanced materials, energy, electronics, environmental science and medicine. The journal accepts original and review articles as well as book reviews for publication. All the manuscripts are single-blind peer-reviewed for scientific quality and acceptance.
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