探讨纳米颗粒对动物胚胎毒性的影响：物理化学性质和生物屏障

IF 2.1 4区材料科学 Q3 CHEMISTRY, MULTIDISCIPLINARY

Journal of Nanoparticle Research Pub Date : 2025-04-23 DOI:10.1007/s11051-025-06322-1

Yue Xu, Xiaomin Wei, Zeqiang Sun

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引用次数: 0

摘要

纳米材料的广泛应用造成了巨大的环境影响，当它们被有意（如在医学中）或无意（环境暴露）引入人类和动物中时，公众对其毒性感到担忧。作为易感人群，孕妇特别容易受到纳米颗粒引起的毒性的影响。然而，这方面的研究仍然有限，即使在“相似”的实验条件下，许多报道的结果也往往不一致。在此，我们讨论了阻碍该研究领域进一步发展的一些有争议的问题。讨论的问题是纳米粒子在物理、化学或生物背景下的真实特性的关键影响，以及怀孕期间妊娠阶段的微妙影响。

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Exploring the impacts of nanoparticles on animal embryotoxicity: physicochemical property and bio-barrier

Wide applications of nanomaterials cause substantial environmental impacts and public concerns over their toxicity when they are intentionally (such as in medicine) or unintentionally (environment exposure) introduced into the human and animals. As a susceptible population, pregnant women are particularly vulnerable to nanoparticle-induced toxicity. However, research in this aspect is still limited and many reported findings are often inconsistent even under the “similar” experimental conditions. Here, we discuss some controversial issues which impeded further progress in this research area. Issues in the discussion are crucial effects of nanoparticles’ true identity in a physical, chemical, or biological context, and the delicate effects of gestational stages during the pregnancy.

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来源期刊

Journal of Nanoparticle Research 工程技术-材料科学：综合

CiteScore

4.40

自引率

4.00%

发文量

198

审稿时长

3.9 months

期刊介绍： The objective of the Journal of Nanoparticle Research is to disseminate knowledge of the physical, chemical and biological phenomena and processes in structures that have at least one lengthscale ranging from molecular to approximately 100 nm (or submicron in some situations), and exhibit improved and novel properties that are a direct result of their small size. Nanoparticle research is a key component of nanoscience, nanoengineering and nanotechnology. The focus of the Journal is on the specific concepts, properties, phenomena, and processes related to particles, tubes, layers, macromolecules, clusters and other finite structures of the nanoscale size range. Synthesis, assembly, transport, reactivity, and stability of such structures are considered. Development of in-situ and ex-situ instrumentation for characterization of nanoparticles and their interfaces should be based on new principles for probing properties and phenomena not well understood at the nanometer scale. Modeling and simulation may include atom-based quantum mechanics; molecular dynamics; single-particle, multi-body and continuum based models; fractals; other methods suitable for modeling particle synthesis, assembling and interaction processes. Realization and application of systems, structures and devices with novel functions obtained via precursor nanoparticles is emphasized. Approaches may include gas-, liquid-, solid-, and vacuum-based processes, size reduction, chemical- and bio-self assembly. Contributions include utilization of nanoparticle systems for enhancing a phenomenon or process and particle assembling into hierarchical structures, as well as formulation and the administration of drugs. Synergistic approaches originating from different disciplines and technologies, and interaction between the research providers and users in this field, are encouraged.