{"title":"Mpox Clade Ib中F13L蛋白的免疫原性表位定位:HLA-B*08和HLA-DRB1*01作为抗原呈递、疾病发病率和致死率的预测因子","authors":"Israel Lara-Vega , Armando Vega-López","doi":"10.1016/j.genrep.2025.102232","DOIUrl":null,"url":null,"abstract":"<div><div>Mpox, an infectious disease caused by the MPXV virus, can lead to painful skin rashes, lymphadenopathy, and fever. While most individuals recover fully, some develop severe illness. The Clade Ib Mpox outbreak is primarily driven by human-to-human transmission, underscoring the urgent need for a coordinated response at national, regional, and international levels. The prediction of epitopes based on human leukocyte antigen (HLA) antigen presentation and their association with disease outcomes forms a crucial basis for developing targeted therapies. This study conducted a bioinformatic prediction of T-cell epitopes and their HLA class I and II-restricted alleles to identify immunogenic epitopes and HLA alleles of the Clade Ib F13L protein of Mpox, an essential protein for viral maturation and the formation of enveloped virions. Moreover, we explored correlations between these epitopes and incidence and lethality rates in hospitalized patients, using data from various regions as an example. We identified a set of 10 epitopes with immunogenic potential and several HLA alleles predicted to efficiently present these epitopes to T cells. Notably, a statistically significant negative correlation was observed between the frequency of HLA-B*08 and HLA-DRB1*01 alleles and incidence and lethality rates in hospitalized patients in Mexico, illustrating potential broader implications.</div></div>","PeriodicalId":12673,"journal":{"name":"Gene Reports","volume":"40 ","pages":"Article 102232"},"PeriodicalIF":1.0000,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Mapping immunogenic epitopes of F13L protein in Mpox Clade Ib: HLA-B*08 and HLA-DRB1*01 as predictors of antigen presentation, disease incidence, and lethality\",\"authors\":\"Israel Lara-Vega , Armando Vega-López\",\"doi\":\"10.1016/j.genrep.2025.102232\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Mpox, an infectious disease caused by the MPXV virus, can lead to painful skin rashes, lymphadenopathy, and fever. While most individuals recover fully, some develop severe illness. The Clade Ib Mpox outbreak is primarily driven by human-to-human transmission, underscoring the urgent need for a coordinated response at national, regional, and international levels. The prediction of epitopes based on human leukocyte antigen (HLA) antigen presentation and their association with disease outcomes forms a crucial basis for developing targeted therapies. This study conducted a bioinformatic prediction of T-cell epitopes and their HLA class I and II-restricted alleles to identify immunogenic epitopes and HLA alleles of the Clade Ib F13L protein of Mpox, an essential protein for viral maturation and the formation of enveloped virions. Moreover, we explored correlations between these epitopes and incidence and lethality rates in hospitalized patients, using data from various regions as an example. We identified a set of 10 epitopes with immunogenic potential and several HLA alleles predicted to efficiently present these epitopes to T cells. Notably, a statistically significant negative correlation was observed between the frequency of HLA-B*08 and HLA-DRB1*01 alleles and incidence and lethality rates in hospitalized patients in Mexico, illustrating potential broader implications.</div></div>\",\"PeriodicalId\":12673,\"journal\":{\"name\":\"Gene Reports\",\"volume\":\"40 \",\"pages\":\"Article 102232\"},\"PeriodicalIF\":1.0000,\"publicationDate\":\"2025-04-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Gene Reports\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2452014425001050\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"GENETICS & HEREDITY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Gene Reports","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2452014425001050","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
Mapping immunogenic epitopes of F13L protein in Mpox Clade Ib: HLA-B*08 and HLA-DRB1*01 as predictors of antigen presentation, disease incidence, and lethality
Mpox, an infectious disease caused by the MPXV virus, can lead to painful skin rashes, lymphadenopathy, and fever. While most individuals recover fully, some develop severe illness. The Clade Ib Mpox outbreak is primarily driven by human-to-human transmission, underscoring the urgent need for a coordinated response at national, regional, and international levels. The prediction of epitopes based on human leukocyte antigen (HLA) antigen presentation and their association with disease outcomes forms a crucial basis for developing targeted therapies. This study conducted a bioinformatic prediction of T-cell epitopes and their HLA class I and II-restricted alleles to identify immunogenic epitopes and HLA alleles of the Clade Ib F13L protein of Mpox, an essential protein for viral maturation and the formation of enveloped virions. Moreover, we explored correlations between these epitopes and incidence and lethality rates in hospitalized patients, using data from various regions as an example. We identified a set of 10 epitopes with immunogenic potential and several HLA alleles predicted to efficiently present these epitopes to T cells. Notably, a statistically significant negative correlation was observed between the frequency of HLA-B*08 and HLA-DRB1*01 alleles and incidence and lethality rates in hospitalized patients in Mexico, illustrating potential broader implications.
Gene ReportsBiochemistry, Genetics and Molecular Biology-Genetics
CiteScore
3.30
自引率
7.70%
发文量
246
审稿时长
49 days
期刊介绍:
Gene Reports publishes papers that focus on the regulation, expression, function and evolution of genes in all biological contexts, including all prokaryotic and eukaryotic organisms, as well as viruses. Gene Reports strives to be a very diverse journal and topics in all fields will be considered for publication. Although not limited to the following, some general topics include: DNA Organization, Replication & Evolution -Focus on genomic DNA (chromosomal organization, comparative genomics, DNA replication, DNA repair, mobile DNA, mitochondrial DNA, chloroplast DNA). Expression & Function - Focus on functional RNAs (microRNAs, tRNAs, rRNAs, mRNA splicing, alternative polyadenylation) Regulation - Focus on processes that mediate gene-read out (epigenetics, chromatin, histone code, transcription, translation, protein degradation). Cell Signaling - Focus on mechanisms that control information flow into the nucleus to control gene expression (kinase and phosphatase pathways controlled by extra-cellular ligands, Wnt, Notch, TGFbeta/BMPs, FGFs, IGFs etc.) Profiling of gene expression and genetic variation - Focus on high throughput approaches (e.g., DeepSeq, ChIP-Seq, Affymetrix microarrays, proteomics) that define gene regulatory circuitry, molecular pathways and protein/protein networks. Genetics - Focus on development in model organisms (e.g., mouse, frog, fruit fly, worm), human genetic variation, population genetics, as well as agricultural and veterinary genetics. Molecular Pathology & Regenerative Medicine - Focus on the deregulation of molecular processes in human diseases and mechanisms supporting regeneration of tissues through pluripotent or multipotent stem cells.