拉丁美洲国家因COVID-19住院的成年人的临床特征、SARS-CoV-2变异和结局

IF 2.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Clinics Pub Date : 2025-01-01 DOI:10.1016/j.clinsp.2025.100648

Constantino López-Macías , Eduardo López-Medina , Maysa Bonfleur Alves , Aline da Rocha Matos , Juan V. Hernández-Villena , Zuleika Aponte-Torres , Laura E. Sarabia , Paula Manrique-Ramirez , Luis F. Tejado-Gallegos , Larisa Ramirez Gutierrez , Wilhelmine Meeraus , Bárbara Emoingt Furtado

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引用次数: 0

摘要

目的covid -19疫苗在全球范围内预防了严重的疾病结局。作为疫苗有效性研究的一部分，作者总结了2022年2月至12月期间拉丁美洲因covid -19样症状住院的患者的人口统计和健康概况、疫苗接种数据、SARS-CoV-2变体以及疾病结果。方法slive是一项观察性前瞻性研究，采用阴性病例对照设计（NCT05282017）。在五个拉丁美洲国家招募了患有covid -19样症状的成年人。对患者进行了SARS-CoV-2检测，并通过测序确定了变体。数据收集自医疗记录和访谈。结果招募的参与者（536例，250例对照）平均年龄为60.5岁。新冠肺炎病例（63.7例，SD = 19.1）略大于对照组（53.8例，SD = 20.4）。心血管系统疾病是最常见的合并症，大多数参与者（73.0%）报告至少有一种合并症。COVID-19病例以中度（51.1%）为主。总体而言，50.6%的参与者未接种COVID-19疫苗，病例比例（56.3%）高于对照组（38.2%）。病毒基因组分析确定了最普遍的SARS-CoV-2谱系，在Omicron BA.5中为BQ.1.1(11.9%)，在重组变体中为XBB.1.15（2.5%）。由于COVID-19住院病例较少，该研究无法评估疫苗的有效性。结论本研究揭示了新冠肺炎住院患者的关键人口学特征和临床特征。值得注意的是，确诊病例中年龄较大，未接种疫苗的人数占很大比例，住院人数减少，这些都强调了拉丁美洲COVID-19形势的复杂性，以及继续开展研究以为公共卫生战略提供信息的必要性。

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Clinical characteristics, SARS-CoV-2 variants, and outcomes of adults hospitalized due to COVID-19 in Latin American countries

Objectives

COVID-19 vaccines prevented severe disease outcomes worldwide. As part of a vaccine effectiveness study, the authors summarized demographic and health profiles, vaccination data, SARS-CoV-2 variants, and disease outcomes from patients hospitalized due to COVID-19-like symptoms in Latin America between February and December 2022.

Methods

LIVE was an observational-prospective study with a test-negative case-control design (NCT05282017). Adults admitted with COVID-19-like symptoms were recruited across five Latin American countries. Patients were tested for SARS-CoV-2, and variants were identified through sequencing. Data were collected from medical records and interviews.

Results

Participants recruited (536 cases, 250 controls) had a mean age of 60.5 years. COVID-19 cases (63.7, SD = 19.1) were slightly older than controls (53.8, SD = 20.4). Disorders of the cardiovascular system were the most prevalent comorbidities, and most participants (73.0 %) reported at least one comorbidity. COVID-19 cases mostly presented with moderate (51.1 %) disease. Overall, 50.6 % of participants were unvaccinated against COVID-19, with a higher percentage in cases (56.3 %) than in controls (38.2 %). Viral genomic analysis identified the most prevalent SARS-CoV-2 lineages, BQ.1.1 (11.9 %) among Omicron BA.5 and XBB.1.15 (2.5 %) among recombinant variants. The study was underpowered to estimate vaccine effectiveness due to the low number of COVID-19 hospitalization cases.

Conclusion

The present study revealed key demographic and clinical characteristics of patients hospitalized due to COVID-19. Notably, an older age among confirmed cases, a substantial proportion of unvaccinated individuals, and the decrease in hospitalizations emphasize the complexity of the COVID-19 landscape in Latin America and the need for continued research to inform public health strategies.

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来源期刊

Clinics 医学-医学：内科

CiteScore

4.10

自引率

3.70%

发文量

129

审稿时长

52 days

期刊介绍： CLINICS is an electronic journal that publishes peer-reviewed articles in continuous flow, of interest to clinicians and researchers in the medical sciences. CLINICS complies with the policies of funding agencies which request or require deposition of the published articles that they fund into publicly available databases. CLINICS supports the position of the International Committee of Medical Journal Editors (ICMJE) on trial registration.