喉癌手术与临床治疗方式的成本-后果分析

IF 2.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Clinics Pub Date : 2025-01-01 DOI:10.1016/j.clinsp.2025.100585

Alexandre Bezerra dos Santos , Patrícia Coelho de Soárez , Rossana Veronica Mendoza Lopez , Luciana Martins Rozman , Alessandro Gonçalves Campolina

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引用次数: 0

摘要

背景喉鳞状细胞癌（LSCC）可作为临床或手术治疗的一种治疗选择。本研究的目的是比较与LSCC治疗相关的直接医疗费用和总生存率。方法回顾性分析2014 - 2017年巴西一家公立医院纳入LSCC患者的成本-后果。单位成本是用宏观成本法估计的。采用倾向评分匹配法。采用Kaplan-Meier法进行生存分析。结果两种治疗方式在总费用方面相似：临床组为32259.65美元，手术组为34385.87美元（p = 0.215）。手术组患者的总生存率优于临床组(HR 0.53；P = 0.047)。结论两种治疗方式治疗LSCC的总费用相近。然而，手术组的总生存率更高。

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Cost-consequence analysis of surgical and clinical treatment modalities of laryngeal cancer

Background

Laryngeal Squamous Cell Carcinoma (LSCC) may be treated clinically or surgically as a therapeutic option with a curative intention. The aim of this study is to compare direct medical costs and overall survival associated with the treatment of LSCC.

Methods

Retrospective cost-consequence analysis, from the perspective of a Brazilian public hospital that included patients with LSCC, from 2014 to 2017. Unit costs were estimated using a macro-costing approach. The Propensity Score Matching method was used. Survival analyses were performed using the Kaplan-Meier method.

Results

The therapeutic modalities were similar in terms of total costs: USD 32,259.65 for the clinical group and USD 34,385.87 for the surgical group (p = 0.215). Patients in the surgical group showed better overall survival than the clinical group (HR 0.53; p = 0.047).

Conclusion

Both therapeutic modalities for the treatment of LSCC showed similar total costs. Nevertheless, overall survival was better in the surgical group.

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来源期刊

Clinics 医学-医学：内科

CiteScore

4.10

自引率

3.70%

发文量

129

审稿时长

52 days

期刊介绍： CLINICS is an electronic journal that publishes peer-reviewed articles in continuous flow, of interest to clinicians and researchers in the medical sciences. CLINICS complies with the policies of funding agencies which request or require deposition of the published articles that they fund into publicly available databases. CLINICS supports the position of the International Committee of Medical Journal Editors (ICMJE) on trial registration.