少年犯脑功能改变：初步meta分析

IF 3.7 2区医学 Q1 PSYCHIATRY

Journal of psychiatric research Pub Date : 2025-04-17 DOI:10.1016/j.jpsychires.2025.04.032

Yong-ming Wang , Jia-sheng Yang , Xin-qi Liu , Qing-wen Bie , Yu-shan Xie , Meng Zhang , Lu-yang Tao , Xi-ping Chen

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引用次数: 0

摘要

青少年犯罪是一个严重的社会问题，对公共安全和精神卫生系统构成重大挑战。然而，青少年犯罪行为背后的神经生理机制仍不清楚。本研究旨在探讨少年犯在静息状态和任务型条件下的脑功能特征。方法在PubMed、Web of Science和MEDLINE上进行全面的文献检索，重点利用全脑静息状态和基于任务的功能磁共振成像（fMRI）研究了少年犯与对照组的大脑激活模式。结果6项基于任务的fMRI研究被纳入meta分析。我们的研究结果显示，在这些基于任务的fMRI研究中，少年犯在额上回（SFG）、杏仁核和小脑蚓部VI区域的左内侧眶部激活增加，在使用情绪任务的研究中，SFG和蚓部VI区域的左内侧眶部激活增加。其他五项静息状态fMRI研究报告了不同的指标。因此，未对静息状态数据进行meta分析。结论前额-杏仁核-小脑回路的过度激活可能是少年犯情绪和行为调节功能受损以及暴力行为增加的重要神经生理基础。

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Brain functional changes in juvenile delinquents: a preliminary meta-analysis

Background

Juvenile delinquency is a serious social issue that poses significant challenges to public safety and mental health systems. However, the neurophysiological mechanisms underlying delinquent behaviour in juveniles remain unclear. In this meta-analysis, we aimed to investigate the functional brain characteristics during resting-state and task-based conditions in juvenile offenders.

Methods

A comprehensive literature search was conducted in PubMed, Web of Science and MEDLINE, focusing on whole-brain resting-state and task-based functional magnetic resonance imaging (fMRI) studies examining brain activation patterns in juvenile delinquents compared with controls.

Results

Six task-based fMRI studies were incorporated into the meta-analysis. Our findings revealed increased activation in juvenile delinquents in the left medial orbital part of the superior frontal gyrus (SFG), amygdala and cerebellum vermis VI region across these task-based fMRI studies, and increased activation in the left medial orbital part of the SFG and vermis VI region in studies using emotional tasks. The other five resting-state fMRI studies reported different indicators. Therefore, no meta-analysis was performed on the resting-state data.

Conclusion

These findings suggest that overactivation in the fronto-amygdala-cerebellar circuit may be a key neurophysiological basis for impaired emotional and behavioural regulation, as well as increased violent behaviour in juvenile offenders.

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来源期刊

Journal of psychiatric research 医学-精神病学

CiteScore

7.30

自引率

2.10%

发文量

622

审稿时长

130 days

期刊介绍： Founded in 1961 to report on the latest work in psychiatry and cognate disciplines, the Journal of Psychiatric Research is dedicated to innovative and timely studies of four important areas of research: (1) clinical studies of all disciplines relating to psychiatric illness, as well as normal human behaviour, including biochemical, physiological, genetic, environmental, social, psychological and epidemiological factors; (2) basic studies pertaining to psychiatry in such fields as neuropsychopharmacology, neuroendocrinology, electrophysiology, genetics, experimental psychology and epidemiology; (3) the growing application of clinical laboratory techniques in psychiatry, including imagery and spectroscopy of the brain, molecular biology and computer sciences;