海藻糖6-磷酸磷酸酶的建模、虚拟筛选、酶对接及邻苯二胺对埃及伊蚊的杀虫效果评价（双翅目：库蚊科）

IF 3.8 1区农林科学 Q1 AGRONOMY

Pest Management Science Pub Date : 2025-04-23 DOI:10.1002/ps.8841

Raquel Jemima Viana Lima, Fernando Berton Zanchi, Railton Marques de Souza Guimarães, Alexandre de Almeida e Silva

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引用次数: 0

摘要

埃及伊蚊是医学上重要的媒介，因为它能传播几种虫媒病毒。本研究以海藻糖途径中的一种酶——海藻糖-6-磷酸磷酸酶（trehalose -6-phosphate phosphatase， TPP）为研究对象，对其进行建模、分子对接并选择潜在配体，评价其对蚊子的杀幼虫和杀成虫活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Modeling, virtual screening, and enzymatic docking of trehalose 6-phosphate phosphatase and evaluation of the insecticidal effect of phthalimide, N-(p-tolylsulfonyl) on Aedes aegypti (Diptera: Culicidae)

查看原文本刊更多论文

Aedes aegypti Linnaeus is a medically important vector because of its role in transmitting several arboviruses. Trehalose-6-phosphate phosphatase (TPP), an enzyme from the trehalose pathway, was the focus of this study, which aimed to model it, perform molecular docking and select potential ligands to evaluate their larvicidal and adulticidal activity on the mosquito.

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来源期刊

Pest Management Science 农林科学-昆虫学

CiteScore

7.90

自引率

9.80%

发文量

553

审稿时长

4.8 months

期刊介绍： Pest Management Science is the international journal of research and development in crop protection and pest control. Since its launch in 1970, the journal has become the premier forum for papers on the discovery, application, and impact on the environment of products and strategies designed for pest management. Published for SCI by John Wiley & Sons Ltd.