Anna K. Selin, Inger Lilliehöök, Emma M. Strage, Anders Larsson, Lena Pelander
{"title":"尿胱抑素C、葡萄糖、尿素和电解质在狗在不同阶段的慢性肾病","authors":"Anna K. Selin, Inger Lilliehöök, Emma M. Strage, Anders Larsson, Lena Pelander","doi":"10.1111/jvim.70090","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>There is limited knowledge of urine analytes in different stages of chronic kidney disease (CKD) in dogs.</p>\n </section>\n \n <section>\n \n <h3> Objectives</h3>\n \n <p>To study markers in urine and fractional excretion (FE) of markers in dogs of different stages of CKD and a healthy control group (C).</p>\n </section>\n \n <section>\n \n <h3> Animals</h3>\n \n <p>Fifty dogs in various stages of CKD and a control group of 30 healthy dogs.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>In this cross-sectional observational study, dogs presenting to a referral hospital and given a diagnosis of CKD using standard methods, and healthy dogs, were included. Urinary cystatin C (uCysC), glucose (uGlu), protein (uProt), creatinine (uCr), urea (uUrea), sodium (uNa), potassium (uK), chloride (uCl), calcium (uCa), and phosphate (uP) were measured with an automated chemistry analyzer. Included analytes were normalized to uCr, FE of electrolytes and urea was calculated, and results compared among groups.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Age, bodyweight, and sex were not different among groups. Urinary CysC/uCr and FE of electrolytes increased with IRIS stage. Median (IQR) for uCysC/uCr was 0.08 (0.04–0.25) 10<sup>−3</sup> in dogs with CKD stage 1 and 0.03 (0.02–0.045) 10<sup>−3</sup> in control dogs (<i>p</i> = 0.0002).</p>\n </section>\n \n <section>\n \n <h3> Conclusion and Clinical Importance</h3>\n \n <p>Urinary CysC might be a potential marker of early CKD, preferably as part of a panel of urinary markers. FE of electrolytes seemed to depend on the serum creatinine level in dogs with azotemic CKD.</p>\n </section>\n </div>","PeriodicalId":49958,"journal":{"name":"Journal of Veterinary Internal Medicine","volume":"39 3","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70090","citationCount":"0","resultStr":"{\"title\":\"Urinary Cystatin C, Glucose, Urea, and Electrolytes in Dogs at Various Stages of Chronic Kidney Disease\",\"authors\":\"Anna K. Selin, Inger Lilliehöök, Emma M. Strage, Anders Larsson, Lena Pelander\",\"doi\":\"10.1111/jvim.70090\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>There is limited knowledge of urine analytes in different stages of chronic kidney disease (CKD) in dogs.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Objectives</h3>\\n \\n <p>To study markers in urine and fractional excretion (FE) of markers in dogs of different stages of CKD and a healthy control group (C).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Animals</h3>\\n \\n <p>Fifty dogs in various stages of CKD and a control group of 30 healthy dogs.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>In this cross-sectional observational study, dogs presenting to a referral hospital and given a diagnosis of CKD using standard methods, and healthy dogs, were included. Urinary cystatin C (uCysC), glucose (uGlu), protein (uProt), creatinine (uCr), urea (uUrea), sodium (uNa), potassium (uK), chloride (uCl), calcium (uCa), and phosphate (uP) were measured with an automated chemistry analyzer. Included analytes were normalized to uCr, FE of electrolytes and urea was calculated, and results compared among groups.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Age, bodyweight, and sex were not different among groups. Urinary CysC/uCr and FE of electrolytes increased with IRIS stage. Median (IQR) for uCysC/uCr was 0.08 (0.04–0.25) 10<sup>−3</sup> in dogs with CKD stage 1 and 0.03 (0.02–0.045) 10<sup>−3</sup> in control dogs (<i>p</i> = 0.0002).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion and Clinical Importance</h3>\\n \\n <p>Urinary CysC might be a potential marker of early CKD, preferably as part of a panel of urinary markers. FE of electrolytes seemed to depend on the serum creatinine level in dogs with azotemic CKD.</p>\\n </section>\\n </div>\",\"PeriodicalId\":49958,\"journal\":{\"name\":\"Journal of Veterinary Internal Medicine\",\"volume\":\"39 3\",\"pages\":\"\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-04-23\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jvim.70090\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Veterinary Internal Medicine\",\"FirstCategoryId\":\"97\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/jvim.70090\",\"RegionNum\":2,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Veterinary Internal Medicine","FirstCategoryId":"97","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/jvim.70090","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
Urinary Cystatin C, Glucose, Urea, and Electrolytes in Dogs at Various Stages of Chronic Kidney Disease
Background
There is limited knowledge of urine analytes in different stages of chronic kidney disease (CKD) in dogs.
Objectives
To study markers in urine and fractional excretion (FE) of markers in dogs of different stages of CKD and a healthy control group (C).
Animals
Fifty dogs in various stages of CKD and a control group of 30 healthy dogs.
Methods
In this cross-sectional observational study, dogs presenting to a referral hospital and given a diagnosis of CKD using standard methods, and healthy dogs, were included. Urinary cystatin C (uCysC), glucose (uGlu), protein (uProt), creatinine (uCr), urea (uUrea), sodium (uNa), potassium (uK), chloride (uCl), calcium (uCa), and phosphate (uP) were measured with an automated chemistry analyzer. Included analytes were normalized to uCr, FE of electrolytes and urea was calculated, and results compared among groups.
Results
Age, bodyweight, and sex were not different among groups. Urinary CysC/uCr and FE of electrolytes increased with IRIS stage. Median (IQR) for uCysC/uCr was 0.08 (0.04–0.25) 10−3 in dogs with CKD stage 1 and 0.03 (0.02–0.045) 10−3 in control dogs (p = 0.0002).
Conclusion and Clinical Importance
Urinary CysC might be a potential marker of early CKD, preferably as part of a panel of urinary markers. FE of electrolytes seemed to depend on the serum creatinine level in dogs with azotemic CKD.
期刊介绍：
The mission of the Journal of Veterinary Internal Medicine is to advance veterinary medical knowledge and improve the lives of animals by publication of authoritative scientific articles of animal diseases.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
