Manreet Kaur, Dr. Shivali Sharma, Dr. Divya Utreja
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A Review on Drug Discovery of Phthalimide Analogues as Emerging Pharmacophores: Synthesis and Biological Potential
Phthalimide is a heterocyclic compound containing a nitrogen atom and two carbonyl groups which form the basis for the synthesis of various natural and synthetic products that are employed in the realms of medicinal chemistry and agrochemicals. It is exploited for synthetic purposes, drug modification and as an agent against various pests due to its versatile structure that offers ease in modifications and effectiveness at a molecular level in biological systems. Incorporating phthalimide with other heterocyclic moieties such as triazole, benzimidazole and piperazine impart consequential structural modifications prompting diversification of repercussions in living systems. This review article seeks to highlight recent achievements in research based on phthalimide compounds stemming from their synthesis followed by their assessment as potent antifungal, antibacterial, antitumor, antioxidant and various other biological agents, and discusses its further potential.
期刊介绍：
ChemistrySelect is the latest journal from ChemPubSoc Europe and Wiley-VCH. It offers researchers a quality society-owned journal in which to publish their work in all areas of chemistry. Manuscripts are evaluated by active researchers to ensure they add meaningfully to the scientific literature, and those accepted are processed quickly to ensure rapid online publication.
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