An overview of the role of steroid hormones in various parasitic infections

There is a close relationship among hormones, neuropeptides, neurotransmitters, and cytokines that modify the host immune response through various effector mechanisms, including both humoral and cellular immunity. Interruption of this communication balance leads to infection or greater vulnerability to disease. The relationship between host and parasite is complex, and there is significant communication, interaction, and biochemical co-evolution. In parasitic infection, the role of various hormones has been proven and there are also reports on parasites the direct effect of hormones. Numerous parasites produce the secretion of molecules that affect the immunological and physiological responses in the host, including intermediaries and vectors. In contrast, the parasite secretes various factors that change the hormone host levels. In a few cases, the parasite's status hormones have negative and positive influences. On the other hand, the influences are indirectly intermediated through the host’s immune system. In vertebrates, the occurrence of parasites also has a main effect on the host endocrine status and a normal suite of processes ruled through hormones. This procedure comprises host growth, establishment, transformation, and reproduction. Therefore, considering the mechanism involved in immuno-endocrine variation and its influences on parasites is critical for emerging new drugs, vaccine target finding, and inventing new therapies for numerous infections. Males are usually more vulnerable to parasitic diseases as compared to females. These sex differentiation can reflect the suppressive properties of testosterone and the excessive effects of estradiol on immune function. For defining the T-cell-driven immunity T. spiralis infection is a perfect model and also provides the crucial visions that can affect potential helminths therapies currently in development. Conflicting host variables regulate the efficiency of such treatment and have recognized the host-derived sex steroid hormones as the main factor in the growth of immunity. This study categorized the role of circulating steroid hormones as an immune regulator in various parasitic diseases.