一例复发性念珠菌菌血症和雷扎芬净的成功治疗

IF 1.1 Q4 INFECTIOUS DISEASES
IDCases Pub Date : 2025-01-01 DOI:10.1016/j.idcr.2025.e02233
Divya Chandramohan , Samantha Aguilar , Gerard Gawrys , Nathan P. Wiederhold , Kristi Traugott , Thomas F. Patterson
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引用次数: 0

摘要

光秃念珠菌的抗真菌耐药性可发展为不同类别的药物,包括唑类和棘白菌素。这种生物已知可引起感染性心内膜炎,尤其偏爱假瓣膜。在这里,我们提出一个复发性真菌血症与C.光秃在中年妇女法洛四联症谁有右心室到肺动脉导管,并经导管肺动脉瓣置换术在过去。她的分离物显示对各种抗真菌药物的最低抑制浓度(MIC)增加,对唑类药物的最低抑制浓度较高,包括对氟康唑的耐药性,导致治疗选择有限。她的假体肺动脉瓣与C. glabrata的痛苦,并使用第二代棘球白素,rezafungin治疗了六个月。这个病例说明了rezafungin长期治疗的耐受性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A case of recurrent Candida glabrata fungemia and successful treatment with rezafungin
Antifungal resistance in Candida glabrata can develop to different classes of drugs, including the azoles and echinocandins. This organism is known to cause infective endocarditis with a particular predilection for prosthetic valves. Herein we present a case of recurrent fungemia with C. glabrata in a middle-aged woman with Tetralogy of Fallot who had a right ventricle to pulmonary artery conduit, and a transcatheter pulmonary valve replacement in the past. Her isolate showed increasing minimum inhibitory concentrations (MIC) to various antifungals with higher MICs to azoles, including resistance to fluconazole, resulting in limited treatment options. She had affliction of her prosthetic pulmonic valve with C. glabrata and was treated with the second-generation echinocandin, rezafungin, for six months. This case illustrates the tolerability profile of long-term treatment with rezafungin.
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来源期刊
IDCases
IDCases INFECTIOUS DISEASES-
CiteScore
2.60
自引率
6.70%
发文量
300
审稿时长
10 weeks
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