大戟科植物中的 Tigliane 和 premyrsinane 二萜及其细胞毒性活性

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-04-14 DOI:10.1016/j.fitote.2025.106525

Atabay Kokanov , Hequn Yang , Dan Tang , Artyk Kokanov , Jiangyu Zhao , Haji Akber Aisa

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引用次数: 0

摘要

从大戟（Euphorbia monostyla）全株中分离得到5个未描述的tigliane和premyrsinane二萜，euphomonophane a - e（1-5）和1个已知的二萜(6)，并通过HRESIMS、1D和2D NMR数据进行了广泛的光谱分析，对它们的化学结构进行了鉴定。新化合物1 ~ 5的绝对结构通过ECD计算重新校核。用MTT法测定了这些二萜类化合物对Hela、MCF7和HCT8癌细胞的细胞毒活性，发现化合物4 （IC50为39.86±2.65 μM）对Hela细胞的细胞毒活性较阿霉素（IC50为0.80±0.03 μM）为中等，而化合物1 ~ 6对MCF7和HCT8细胞无细胞毒活性。

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Tigliane and premyrsinane diterpenoids from Euphorbia monostyla and their cytotoxic activity

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Tigliane and premyrsinane diterpenoids from Euphorbia monostyla and their cytotoxic activity

Five undescribed tigliane and premyrsinane diterpenoids, euphomonophane A-E (1–5), along with a known diterpenoid (6), were isolated from the whole plant of Euphorbia monostyla, and their chemical structures were elucidated based on extensive spectroscopic analysis, including HRESIMS, 1D and 2D NMR data. The absolute structures of new compounds 1–5 were rechecked by ECD calculation. These diterpenoids were evaluated for their cytotoxic activity on the cancer cell line Hela, MCF7, and HCT8 by MTT assay and compounds 4 (IC₅₀ 39.86 ± 2.65 μM) revealed moderate cytotoxic potential against Hela cells compared to Doxorubicin (DOX, IC₅₀ 0.80 ± 0.03 μM), while compounds 1–6 possessed no cytotoxicity against MCF7 and HCT8 cells.

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.