One-pot single step process for synthesis of lincomycin to clindamycin: A straightforward, environmentally friendly, robust, and economically viable featuring fewer impurities

Clindamycin derivatives stand for its high biological activity and practical clinical application. These antibiotics exert bacteriostatic effects at higher concentrations also. As the biological and clinical applications of the clindamycin are well known, this discovery describes the two distinct methods for synthesizing clindamycin from lincomycin. The prior art methods for synthesizing clindamycin are known but it required a straightforward, environmentally friendly, cost-effective, and single-step method for producing clindamycin from lincomycin. The researchers have thoroughly explored and successfully developed a novel approach for synthesis of clindamycin. The proposed synthesis routes and concise procedures for synthesizing clindamycin are outlined here. The analytical data supports the same which includes HPLC data for purity, PMR, ¹³CMR and mass spectra for molecular mass and structural determination. XRD withparticle size calculation for crystalline structure and particle size distributions are studied for synthesized clindamycin.