tfoh催化pph3促进亲核环化反应合成功能化(Z)-2-亚氨基苯并[e][1,3]噻嗪-4-酮

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-04-21 DOI:10.1016/j.tet.2025.134676

Lirong Jiang, Jiayang Zhang, Xiaolu Li, Xuan Tang, Shuwen Gong, Xianqiang Huang, Guodong Shen

引用次数: 0

摘要

报道了以苯并[c][1,2]二巯基-3-酮和碳二酰亚胺为原料，采用tfoh催化pph3促进的亲核环化反应合成(Z)-2-亚氨基苯并[e][1,3]噻嗪-4-酮的第一例。亲核环化反应为在温和的反应条件下获得各种功能化(Z)-2-亚胺-苯并噻唑酮提供了新的简捷途径，具有重要的生物学和合成意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

TfOH-catalyzed PPh3-promoted nucleophilic cyclization reactions for the synthesis of functionalized (Z)-2-imino-benzo[e][1,3]thiazin-4-ones

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TfOH-catalyzed PPh3-promoted nucleophilic cyclization reactions for the synthesis of functionalized (Z)-2-imino-benzo[e][1,3]thiazin-4-ones

The first example of an effective TfOH-catalyzed PPh₃-promoted nucleophilic cyclization reaction for the synthesis of (Z)-2-imino-benzo[e ][1,3]thiazin-4-ones via benzo [c] [1,2]dithiol-3-ones and carbodiimides have been developed. The nucleophilic cyclization reaction offers new concise routes to access various functionalized (Z)-2-imino-benzothiazinones in moderate to excellent yields under mild reaction conditions, which are of biological and synthetic importance.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.