Xinxin Ma, Yueying Liu, Miaoxian Xie, Chunmei Li, Xinyang Li, Dandan Shang, Min Chen, Haibo Chen, Wen Su
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引用次数: 0
摘要
本研究旨在利用沿血管周围间隙扩散张量图像分析（DTI-ALPS）方法评估伴有和不伴有快速眼动睡眠行为障碍（RBD）的帕金森病（PD）的淋巴系统活性。总共招募了91名PD患者和33名健康对照者。根据RBD量表将PD患者分为PD-RBD组（n = 55）和PD- nrbd组（n = 36）。计算alps指数和血管周围空间增大（EPVS）评分。在控制年龄影响后，PD-RBD组alps指数低于PD-nRBD组和对照组（p = 0.018和p = 0.001）。PD-RBD组UPDRS part I和HAMD评分高于PD-nRBD组。RBD症状与PD患者alps指数独立相关（β = - 0.259, p = 0.014）。总之，与没有RBD的PD相比，可能有RBD的PD与更严重的淋巴系统功能障碍和非运动症状相关。
Parkinson’s disease with possible REM sleep behavior disorder correlated with more severe glymphatic system dysfunction
This study aimed to evaluate the glymphatic system activity in Parkinson’s disease (PD) with and without rapid eye movement sleep behavior disorder (RBD) using the diffusion tensor image analysis along the perivascular space (DTI-ALPS) methods. Overall, 91 patients with PD and 33 healthy controls were recruited. PD patients were divided into PD-RBD (n = 55) and PD-nRBD (n = 36) groups according to RBD scales. The ALPS-index and enlarged perivascular spaces (EPVS) scores were calculated. PD-RBD group exhibited lower ALPS-index than PD-nRBD and controls after controlling for the effect of age (p = 0.018 and p = 0.001). PD-RBD group showed higher UPDRS part I and HAMD score than those in PD-nRBD group. RBD symptom was independently correlated with ALPS-index in PD (β = −0.259, p = 0.014). In conclusion, PD with possible RBD correlated with more severe glymphatic system dysfunction and non-motor symptoms than those in PD without RBD.
期刊介绍：
npj Parkinson's Disease is a comprehensive open access journal that covers a wide range of research areas related to Parkinson's disease. It publishes original studies in basic science, translational research, and clinical investigations. The journal is dedicated to advancing our understanding of Parkinson's disease by exploring various aspects such as anatomy, etiology, genetics, cellular and molecular physiology, neurophysiology, epidemiology, and therapeutic development. By providing free and immediate access to the scientific and Parkinson's disease community, npj Parkinson's Disease promotes collaboration and knowledge sharing among researchers and healthcare professionals.
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