在氯化铝存在下一次锅四组份顺序高效合成 5-乙酰基-4-氨基-3-(芳基)噻吩并[2,3-b]吡啶-6(7H)-酮

IF 2.1 3区化学 Q2 CHEMISTRY, ORGANIC

Tetrahedron Pub Date : 2025-04-19 DOI:10.1016/j.tet.2025.134673

Hossein Mehrabi, Farzaneh Alizadeh-Bami, Zeynab Mohammadi

引用次数: 0

摘要

报道了在回流条件下，2-（1-芳基）丙二腈、单质硫和Meldrum酸在1,2-二氯乙烷中以AlCl3（15摩尔%）存在，一锅两步反应合成5-乙酰基-4-氨基-3-（芳基）噻吩[2,3-b]吡啶-6(7H)- 1的简单高效方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Efficient one-pot four-component sequential synthesis of 5-acetyl-4-amino-3-(aryl)thieno[2,3-b]pyridin-6(7H)-ones in the presence of aluminum chloride

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Efficient one-pot four-component sequential synthesis of 5-acetyl-4-amino-3-(aryl)thieno[2,3-b]pyridin-6(7H)-ones in the presence of aluminum chloride

A simple and efficient procedure for the synthesis of 5-acetyl-4-amino-3-(aryl)thieno[2,3-b]pyridin-6(7H)-ones by one-pot two-step reaction between 2-(1-arylethylidene)malononitriles, elemental sulfur, and Meldrum's acid in the presence of AlCl₃ (15 mol %) in 1,2-dichloroethane under refluxing conditions is reported.

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来源期刊

Tetrahedron 化学-有机化学

CiteScore

3.90

自引率

4.80%

发文量

439

审稿时长

34 days

期刊介绍： Tetrahedron publishes full accounts of research having outstanding significance in the broad field of organic chemistry and its related disciplines, such as organic materials and bio-organic chemistry. Regular papers in Tetrahedron are expected to represent detailed accounts of an original study having substantially greater scope and details than that found in a communication, as published in Tetrahedron Letters. Tetrahedron also publishes thematic collections of papers as special issues and ''Reports'', commissioned in-depth reviews providing a comprehensive overview of a research area.