果胶乳凝胶：不同低甲氧基果胶对姜黄素负载和结肠靶向释放的影响

IF 11 1区农林科学 Q1 CHEMISTRY, APPLIED

Food Hydrocolloids Pub Date : 2025-04-17 DOI:10.1016/j.foodhyd.2025.111461

Muhammad Muntaqeem Arain , Ruoxuan Li , Qin Chen , Shuixian Huang , Yanbing Zhang , Yitong Liu , Siyi Pan , Fengxia Liu

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引用次数: 0

摘要

高静水压力辅助果胶酶解酯化（hhp - pecin）显著提高了低甲氧基果胶（LMP）的乳凝胶性能。然而，以hhp -果胶为基础的乳液凝胶对负载和控制递送的影响尚未被探索。在本研究中，hhp -果胶乳液凝胶中装载姜黄素，并以dm5 ~ 10%的碱性去酯化LMP （a -果胶）作为对照。结果表明，姜黄素在LMP乳液凝胶结构中包封良好，包封效率（EE）显著提高，达到92.55±2.19%。在相同DM（5 ~ 10%）下，hhp -果胶乳液凝胶比a -果胶具有更致密的结构和均匀的包装，显著提高了姜黄素的光稳定性和热稳定性，紫外线处理18 h和热处理90 min后，姜黄素的保留率分别为70.91±1.07%和79.91±2.35%。LMP乳剂凝胶能显著抑制姜黄素在口腔、胃和小肠的释放，且在DM较低时，其在结肠的缓释效果较好。在相同DM下，hhp -果胶比a -果胶具有更高的结肠姜黄素缓释率（89.03±0.76%），这主要是由于hhp -果胶的分子量（Mw）和黏度更高。因此，这些结果表明，HHP显著提高了LMP乳液凝胶作为结肠靶向递送的有效载体及其在食品和药品工业中的应用潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Pectin emulsion gel: Effect of different low-methoxyl pectin on loading and colon-targeted release of curcumin

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Pectin emulsion gel: Effect of different low-methoxyl pectin on loading and colon-targeted release of curcumin

High hydrostatic pressure-assisted enzymatic de-esterification of pectin (HHP-pectin) significantly enhanced the emul-gelling properties of low-methoxyl pectin (LMP). However, the effect of HHP-pectin-based emulsion gel on loading and controlled delivery has not been explored yet. In this study, emulsion gels of HHP-pectin were loaded with curcumin, and alkaline de-esterified LMP (A-pectin) with DM 5∼10 % was used as a control. It was found that curcumin was well encapsulated in LMP emulsion gel structure, and the encapsulation efficiency (EE) increased significantly, reaching 92.55 ± 2.19 %. At the same DM (5∼10 %), emulsion gel of HHP-pectin had more dense structure with uniform packing than that of A-pectin, that significantly improved light and thermal stability of curcumin, with retention rate of about 70.91 ± 1.07 % and 79.91 ± 2.35 % after 18 h of ultraviolet light treatment and 90 min of thermal treatment, respectively. LMP emulsion gels could significantly inhibit the release of curcumin in the oral, stomach, and small intestine, and at lower DM, it had a better-sustained release effect in the colon. At the same DM, HHP-pectin had a higher and sustained release of curcumin (89.03 ± 0.76 %) in the colon than A-pectin, mainly attributed to higher molecular weight (Mw) and viscosity of HHP-pectin. Thus, these results suggested that HHP significantly improved the potential of LMP emulsion gels as an effective carrier for colon-targeted delivery and its application in the food and drug industries.

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来源期刊

Food Hydrocolloids 工程技术-食品科技

CiteScore

19.90

自引率

14.00%

发文量

871

审稿时长

37 days

期刊介绍： Food Hydrocolloids publishes original and innovative research focused on the characterization, functional properties, and applications of hydrocolloid materials used in food products. These hydrocolloids, defined as polysaccharides and proteins of commercial importance, are added to control aspects such as texture, stability, rheology, and sensory properties. The research's primary emphasis should be on the hydrocolloids themselves, with thorough descriptions of their source, nature, and physicochemical characteristics. Manuscripts are expected to clearly outline specific aims and objectives, include a fundamental discussion of research findings at the molecular level, and address the significance of the results. Studies on hydrocolloids in complex formulations should concentrate on their overall properties and mechanisms of action, while simple formulation development studies may not be considered for publication. The main areas of interest are: -Chemical and physicochemical characterisation Thermal properties including glass transitions and conformational changes- Rheological properties including viscosity, viscoelastic properties and gelation behaviour- The influence on organoleptic properties- Interfacial properties including stabilisation of dispersions, emulsions and foams- Film forming properties with application to edible films and active packaging- Encapsulation and controlled release of active compounds- The influence on health including their role as dietary fibre- Manipulation of hydrocolloid structure and functionality through chemical, biochemical and physical processes- New hydrocolloids and hydrocolloid sources of commercial potential. The Journal also publishes Review articles that provide an overview of the latest developments in topics of specific interest to researchers in this field of activity.