美国年轻人感染性心内膜炎死亡率的趋势：一个令人担忧的上升及其与药物滥用的关系

IF 1.9 Q3 PERIPHERAL VASCULAR DISEASE

International Journal of Cardiology Cardiovascular Risk and Prevention Pub Date : 2025-04-15 DOI:10.1016/j.ijcrp.2025.200404

Ali Bin Abdul Jabbar , Daniyal Ali Khan , May Li-Jedras , Amjad Kabach , Ahmed Aboeata

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引用次数: 0

摘要

在美国的年轻人中，药物滥用（SA）与感染性心内膜炎（IE）的发病率和死亡率相关。然而，关于美国年轻人IE死亡率及其与SA关联的趋势和差异的数据有限。方法分析1999年至2022年美国15至44岁年轻人IE和sa -IE相关死亡率的数据，这些数据来自疾病控制和预防中心的流行病学研究广泛在线数据。使用Joinpoint回归分析，使用每100万人的年龄调整死亡率（AAMR）来计算年度百分比变化（APC）。趋势按性别、种族/民族、年龄组、人口普查地区、城市化分类和州进行分层。结果，在1999年至2022年期间，美国年轻人中有22,614人死亡。其中7235例（32.0%）死亡与SA相关。ie相关死亡率的AAMR最初从1999年的6.2下降到2010年的4.7。此后，这一数字增长了近3倍，在2020年和2021年达到13.5。SA-IE的AAMR也有类似的趋势，从2010年的1.0增加到2018年的5.4，增长了5倍多。1999年至2009年期间，每年15 - 22%的IE死亡与SA相关，2016-2022年这一比例增加到40%。男性对IE的AAMR更高，但女性与sa相关的IE死亡率上升幅度更大。非西班牙裔美国印第安人、阿拉斯加原住民、南部地区和农村人口的增幅更大。结论：自2010年以来，美国年轻成人的sie死亡率有所上升，SA和ie相关的死亡率也有所上升。

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Trends of infective endocarditis mortality in young adult population of US: A concerning rise and its association with substance abuse

Background

Substance Abuse (SA) is associated with Infective Endocarditis (IE) morbidity and mortality in the young adult population of the US. However, limited data is available for trends and disparities related to IE mortality and its association with SA in the young adult US population.

Methods

Data from the Centers for Disease Control and Prevention Wide-ranging Online Data for Epidemiologic Research were analyzed from 1999 to 2022 for IE and SA-IE-related mortality in young adults aged 15 to 44 in the US. Age-adjusted mortality rates (AAMR) per 1000,000 people were used to calculate annual percent changes (APC) using Joinpoint regression analysis. Trends were stratified by sex, race/ethnicity, age groups, census region, urbanization classification, and states.

Results

IE caused 22,614 deaths in the young adult population of the US between 1999 and 2022. 7235 (32.0 %) of these deaths were associated with SA. AAMR for IE-associated mortality initially decreased from 6.2 in 1999 to 4.7 in 2010. Following that it increased by almost 3 folds to reach 13.5 in 2020 and 2021. SA-IE followed a similar trend, increasing more than 5 folds from an AAMR of 1.0 in 2010 to 5.4 by 2018. Between 1999 and 2009, 15–22 % of all IE deaths were associated with SA annually, which increased to >40 % for 2016–2022. Men had higher AAMR for IE though women witnessed a bigger jump in SA-associated IE mortality. Non-Hispanic American Indian or Alaskan natives, South region, and rural population had a worse increase.