提高硝基苯硝化选择性和安全性的连续流微反应器系统

IF 3.7 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

ACS Omega Pub Date : 2025-04-09 DOI:10.1021/acsomega.5c0037710.1021/acsomega.5c00377

Wenyuan Zhao, Simeng Wang, Wenxian Zhao, Wei wei and Dongmao Yan*,

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引用次数: 0

摘要

二硝基苯是农药和染料生产中的重要中间体，通常是通过硝基苯的放热硝化合成的。为了提高硝化过程的选择性和安全性，提出了一种集成微混合器的连续流微反应器系统。开发了一个开源Python程序来精确控制硝基苯与混合酸的质量流量比。通过优化反应条件，采用十二烷基硫酸钠（SDS）作为表面活性剂，对二硝基苯的选择性降至0.44%，有害硝基酚副产物降至112 ppm，与传统间歇式工艺的509 ppm相比有显著提高。与传统间歇式反应器相比，微反应器系统显著降低了对二硝基苯的选择性，最大限度地减少了硝基苯和三硝基苯的生成，突出了其工业规模应用的适用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Continuous-Flow Microreactor System for Enhanced Selectivity and Safety in Nitrobenzene Nitration

Dinitrobenzene, a crucial intermediate in pesticide and dye production, is typically synthesized through the exothermic nitration of nitrobenzene. This study presents a continuous-flow microreactor system integrated with micromixers to enhance selectivity and safety in the nitration process. An open-source Python program was developed to precisely control the mass flow rate ratio of nitrobenzene to the mixed acid. By optimizing reaction conditions and employing sodium dodecyl sulfate (SDS) as a surfactant, the selectivity of p-dinitrobenzene was minimized to 0.44%, while hazardous nitrophenol byproducts were reduced to 112 ppm─a significant improvement compared to the 509 ppm observed in traditional batch processes. Compared to traditional batch reactors, the microreactor system significantly lowered p-dinitrobenzene selectivity and minimized nitrophenol and trinitrobenzene formation, highlighting its suitability for industrial-scale applications.

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来源期刊

ACS Omega Chemical Engineering-General Chemical Engineering

CiteScore

6.60

自引率

4.90%

发文量

3945

审稿时长

2.4 months

期刊介绍： ACS Omega is an open-access global publication for scientific articles that describe new findings in chemistry and interfacing areas of science, without any perceived evaluation of immediate impact.