区域选择性C-C和C-S键合成h -异硫代铬

IF 4.3 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-04-21 DOI:10.1039/d5cc01269d

Kelu Yan, Yuhang Sun, Jiangwei Wen, Qiuyun Li, Xinming Yu, Wenxu Shang, Xiu Wang

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引用次数: 0

摘要

铑催化的硫定向C-H键活化和氨基硫酮与炔的串联环化反应进行得很顺利。大多数具有不同取代基的h -异硫代铬的产物都是通过区域选择性的C-C和C-S键形成而获得高产率的。与传统合成h -异硫代铬的方法相比，该方法具有偶联底物稳定易得、一锅操作简单、步骤经济、原子经济、含硫杂环产物高度独特等优点。

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Synthesis of 1H-Isothiochromenes by Regioselective C–C and C–S Bonds Formation of Enaminothiones with Alkynes under Rhodium Catalysis

The rhodium-catalyzed sulfur-directed C–H bond activation and tandem cyclization of enaminothiones with alkynes proceed efficiently. Most products of 1H-isothiochromenes with various substituents are achieved in good yields by regioselective C–C and C–S bonds formation. This protocol has some advantages over the traditional methods in synthesizing 1H-isothiochromenes in terms of stable and easy available coupling substrates, simple and one-pot operation, step and atom economy, and highly unique sulfur-containing heterocyclic products.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.