含氟液晶单体在母婴配对尿液中的分布

IF 7.6 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Pollution Pub Date : 2025-04-21 DOI:10.1016/j.envpol.2025.126283

Runhui Yang , Yanli Zhang , Qun Gao , Chenhui Sang , Yumin Niu , Shiyu Du , Bing Shao

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引用次数: 0

摘要

氟化液晶单体（flcm）是广泛存在的环境污染物，具有潜在的内分泌干扰作用。婴儿尤其容易受到影响，但他们的暴露程度尚不清楚。本研究分析了北京190对母婴尿液样本中的flcm，分别检测到34和35个flcm。母亲校正后的中位肌酐浓度为1.83 μg/g（未校正浓度为1.28 ng/mL），婴儿为3.28 μg/g （0.60 ng/mL）。1-丁氧基-2,3-二氟-4-（反式-4-丙基环己基）苯（BDPrB）和1-乙基-4-[（4-氟苯基）乙基]苯（EFPEB）被确定为主要检测污染物。只有2'-氟-4 " -丙基-[1,1':4',1 " -terphenyl]-4-carbonitrile （FPTC）在母亲和婴儿的尿液浓度之间存在显著的正相关（rs = 0.23, p = 0.023）。某些flcm与婴儿喂养方式、产妇胎次和环境暴露有关，包括灰尘和清洁频率(p <；0.05)。研究结果显示，母亲和婴儿的平均每日摄入(EDIs)∑flcm分别为526和425 ng/kg bw/day，两者之间无显著差异(p >；0.05)。进一步按性别分层的数据显示，对于男婴，BDPrB和EFPEB的EDI值更大(p <；0.05)。这些发现强调需要对flcm对婴儿的健康影响进行更多的研究，特别是考虑到性别差异。

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Fluorinated liquid-crystal monomers distribution in paired urine from mothers and infants

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Fluorinated liquid-crystal monomers distribution in paired urine from mothers and infants

Fluorinated liquid-crystal monomers (FLCMs) are widespread environmental contaminants with potential endocrine-disrupting effects. Infants are particularly vulnerable, yet their exposure remains unclear. This study analyzed FLCMs in urine samples from 190 paired mothers and infants in Beijing, detecting 34 and 35 FLCMs, respectively. Median creatinine-corrected concentrations were 1.83 μg/g (unadjusted concentrations: 1.28 ng/mL) for mothers and 3.28 μg/g (0.60 ng/mL) for infants. 1-butoxy-2,3-difluoro-4-(trans-4-propylcyclohexyl) benzene (BDPrB) and 1-ethyl-4-[(4-fluorophenyl) ethynyl] benzene (EFPEB) were identified as the primary detected contaminants. A significant positive correlation in urine concentrations between mothers and infants was observed only for 2′-Fluoro-4″-propyl-[1,1':4′,1″-terphenyl]-4-carbonitrile (FPTC) (r_s = 0.23, p = 0.023). Certain FLCMs were associated with infant feeding patterns, maternal parity, and environmental exposure, including dust and cleaning frequency (p < 0.05). The results of the study showed that the median estimated daily intakes (EDIs) of ∑FLCMs for mothers and infants were 526 and 425 ng/kg bw/day, respectively, with no significant difference between them (p > 0.05). Further stratification of the data by sex revealed that for male infants, the EDI values for BDPrB and EFPEB were greater (p < 0.05). These findings emphasize the need for greater research on the health effects of FLCMs on infants, particularly considering gender differences.

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来源期刊

Environmental Pollution 环境科学-环境科学

CiteScore

16.00

自引率

6.70%

发文量

2082

审稿时长

2.9 months

期刊介绍： Environmental Pollution is an international peer-reviewed journal that publishes high-quality research papers and review articles covering all aspects of environmental pollution and its impacts on ecosystems and human health. Subject areas include, but are not limited to: • Sources and occurrences of pollutants that are clearly defined and measured in environmental compartments, food and food-related items, and human bodies; • Interlinks between contaminant exposure and biological, ecological, and human health effects, including those of climate change; • Contaminants of emerging concerns (including but not limited to antibiotic resistant microorganisms or genes, microplastics/nanoplastics, electronic wastes, light, and noise) and/or their biological, ecological, or human health effects; • Laboratory and field studies on the remediation/mitigation of environmental pollution via new techniques and with clear links to biological, ecological, or human health effects; • Modeling of pollution processes, patterns, or trends that is of clear environmental and/or human health interest; • New techniques that measure and examine environmental occurrences, transport, behavior, and effects of pollutants within the environment or the laboratory, provided that they can be clearly used to address problems within regional or global environmental compartments.