驱动皮层神经元规格的基因程序

IF 21.2 1区医学 Q1 NEUROSCIENCES

Nature neuroscience Pub Date : 2025-04-21 DOI:10.1038/s41593-025-01934-1

Zhisong He, Barbara Treutlein

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引用次数: 0

摘要

人类大脑的大脑皮层是至关重要和复杂的，包括不同的神经元亚型，需要在发育过程中指定。目前尚不清楚这一过程是如何受到监管的。在本期的《自然神经科学》中，Nano等人整理并挖掘了人类皮层发育的细胞图谱纲要，以确定驱动神经元亚型规范的基因程序，并使用脑类器官模型验证机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Gene programs driving cortical neuron specifications

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Gene programs driving cortical neuron specifications

The cerebral cortex of the human brain is crucial and complex, and includes different subtypes of neuron that need to be specified during development. How this process is regulated is unclear. In this issue of Nature Neuroscience, Nano et al. curate and mine a compendium cell atlas of human cortical development to identify gene programs that drive neuron subtype specification and validate a mechanism using brain organoid models.

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来源期刊

Nature neuroscience 医学-神经科学

CiteScore

38.60

自引率

1.20%

发文量

212

审稿时长

1 months

期刊介绍： Nature Neuroscience, a multidisciplinary journal, publishes papers of the utmost quality and significance across all realms of neuroscience. The editors welcome contributions spanning molecular, cellular, systems, and cognitive neuroscience, along with psychophysics, computational modeling, and nervous system disorders. While no area is off-limits, studies offering fundamental insights into nervous system function receive priority. The journal offers high visibility to both readers and authors, fostering interdisciplinary communication and accessibility to a broad audience. It maintains high standards of copy editing and production, rigorous peer review, rapid publication, and operates independently from academic societies and other vested interests. In addition to primary research, Nature Neuroscience features news and views, reviews, editorials, commentaries, perspectives, book reviews, and correspondence, aiming to serve as the voice of the global neuroscience community.