氯化铵是一种环境污染物,通过调节黑素小体和自噬来破坏黑素细胞的生物学

IF 6.1 2区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES
Sae Woong Oh , Eunbi Yu , See-Hyoung Park , Kitae Kwon , Jung Hyun Lee , Heejun Ha , Gyeonghyeon Kim , Hee Seon Shin , Seokhyeon Min , Minkyung Song , Jae Youl Cho , Jongsung Lee
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引用次数: 0

摘要

氯化铵是一种由工业排放、混凝土、室内细菌或其他来源释放的室内环境污染物。在这项研究中,我们表征了氯化铵诱导的黑素细胞损伤的分子机制,黑素细胞是色素沉着的关键效应物。具体来说,我们研究了氯化铵对色素沉着的影响及其潜在机制,包括其参与黑色素形成和自噬。基于实验,我们阐明了氯化铵通过akt介导的黑色素生成信号通路上调MITF诱导和增加黑色素生成。此外,氯化铵不表现出溶体性活性,并通过激活AKT-mTOR信号通路抑制自噬,提示氯化铵的色素调节机制与色素细胞的自噬有关。本研究结果为氯化铵诱导色素沉着的机制提供了新的视角,并提出了一种利用联合自噬诱导剂减轻氯化铵诱导的色素沉着和高氨血症等副作用的潜在方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Ammonium chloride, an environmental pollutant, disrupts melanocyte biology through the regulation of melanosome and autophagy
Ammonium chloride is an indoor environmental pollutant released due to industrial emissions, concrete, indoor bacteria, or other sources. In this study, we characterized molecular mechanisms of ammonium chloride-induced cell damage in melanocyte cells, which are a critical effector for pigmentation. Specifically, we investigated the effects of ammonium chloride on pigmentation and its underlying mechanisms, including its involvement in melanogenesis and autophagy. Based on the experiments, we elucidated that ammonium chloride induced and increased melanogenesis by upregulating MITF via AKT-mediated melanogenic signaling pathways. Moreover, ammonium chloride did not exhibit lysosomotropic activity and inhibited autophagy by activating the AKT-mTOR signaling pathway, suggesting that the pigment-regulating mechanism of ammonium chloride was associated with autophagy in pigmented cells. The findings of this study offer new perspectives on the mechanisms involved in ammonium chloride-induced pigmentation and propose a potential approach to mitigate ammonium chloride-induced side effects like hyperpigmentation and hyperammonemia by employing a combined autophagy inducer.
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来源期刊
CiteScore
12.10
自引率
5.90%
发文量
1234
审稿时长
88 days
期刊介绍: Ecotoxicology and Environmental Safety is a multi-disciplinary journal that focuses on understanding the exposure and effects of environmental contamination on organisms including human health. The scope of the journal covers three main themes. The topics within these themes, indicated below, include (but are not limited to) the following: Ecotoxicology、Environmental Chemistry、Environmental Safety etc.
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