慢性阻塞性肺疾病（COPD）患者血液中的调节性T细胞：系统回顾和荟萃分析

IF 3.5 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Respiratory medicine Pub Date : 2025-04-15 DOI:10.1016/j.rmed.2025.108104

Mobina Jalalvand , Hanieh Tahermohammadi , Elham Madreseh , Mohammad Varahram , Hooman Sharifi , Maryam Akhtari , Hamidreza Jamaati

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引用次数: 0

摘要

背景慢性阻塞性肺病（COPD）是导致全球死亡和发病的主要原因之一。由于慢性阻塞性肺病缺乏有效的治疗方法，以调节性 T 细胞（Treg）为靶点的治疗方法最近引起了广泛关注。因此，我们进行了一项系统性回顾和荟萃分析，回顾了有关 COPD 患者外周血样本中 Treg 细胞比例的所有现有数据，以发现这些细胞在为这些患者寻找新疗法方面的潜在作用。提取的数据包括慢性阻塞性肺病患者和健康受试者的人数、Treg 细胞的鉴定、Treg 细胞标记物的定义、慢性阻塞性肺病患者和对照组中 Treg 的百分比，以及慢性阻塞性肺病患者的吸烟情况和临床状态。根据定义 Treg 的标记物、慢性阻塞性肺病患者的临床状态和患者的吸烟史进行亚组分析，也未观察到 Treg 频率的明显差异。根据我们的研究结果，吸烟会降低体内 Treg 细胞的水平。与不吸烟的健康人相比，吸烟者血液中 CD4+CD25+FoxP3+ Tregs 的频率要低得多。

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Regulatory T cells in the blood of patients with chronic obstructive pulmonary disease (COPD): A systematic review and meta-analysis

Background

Chronic obstructive pulmonary disease (COPD) ranks among the leading causes of mortality and morbidity worldwide. Due to the lack of effective treatments for COPD, targeting regulatory T-cells (Treg) has recently attracted considerable attention. Therefore, we conducted a systematic review and meta-analysis to review all of the existing data about the percentage of Treg cells in peripheral blood samples of COPD patients to discover the potential role of these cells in finding new treatments for these patients.

Methods

We explored SCOPUS, PubMed, and Web of Science databases using search terms like “Chronic obstructive pulmonary disease”, “Emphysema”, “suppressive lymphocyte”, and “Regulatory T Cell”. Data regarding the number of COPD patients and healthy subjects, Treg cell identification, definition of Treg cell markers, and the percentage of Tregs in COPD patients and controls, in addition to smoking, and clinical status of COPD patients were extracted.

Results

The overall assessment showed no significant difference in the frequency of Treg cells between COPD patients and healthy subjects. No remarkable difference in Treg frequencies was observed in subgroup analysis based on the markers used to define Tregs, the clinical state of COPD patients, and the patient's smoking history. Based on our results, smoking reduces the level of Treg cells in the body. The frequency of CD4⁺CD25⁺FoxP3⁺ Tregs was considerably lower in the blood of smokers than in non-smoking healthy individuals.

Conclusion

The overall result of this meta-analysis points out the importance of smoking in the prevalence of peripheral blood Treg cells.

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来源期刊

Respiratory medicine 医学-呼吸系统

CiteScore

7.50

自引率

0.00%

发文量

199

审稿时长

38 days

期刊介绍： Respiratory Medicine is an internationally-renowned journal devoted to the rapid publication of clinically-relevant respiratory medicine research. It combines cutting-edge original research with state-of-the-art reviews dealing with all aspects of respiratory diseases and therapeutic interventions. Topics include adult and paediatric medicine, epidemiology, immunology and cell biology, physiology, occupational disorders, and the role of allergens and pollutants. Respiratory Medicine is increasingly the journal of choice for publication of phased trial work, commenting on effectiveness, dosage and methods of action.