男性生殖器官甲基苯丙胺定量分析的法医学意义

IF 1.3 4区医学 Q3 MEDICINE, LEGAL

Legal Medicine Pub Date : 2025-04-11 DOI:10.1016/j.legalmed.2025.102618

Naoto Tani, Shigeki Oritani, Mayumi Ono, Takaki Ishikawa

{"title":"男性生殖器官甲基苯丙胺定量分析的法医学意义","authors":"Naoto Tani, Shigeki Oritani, Mayumi Ono, Takaki Ishikawa","doi":"10.1016/j.legalmed.2025.102618","DOIUrl":null,"url":null,"abstract":"<div><div>The present study measured concentrations of methamphetamine (MA) and its metabolite amphetamine (AMP) in male reproductive organs and investigated the significance of detecting these stimulants in the reproductive organs and the associated pharmacokinetics. The study examined the left and right testes and prostate from 28 male autopsy cases in which MA had been detected. Concentrations of MA and AMP in the left and right testes and prostate were quantified and compared with concentrations in right heart blood, iliac vein blood, and urine. No correlations were found between MA or AMP concentrations and post-mortem time at any sampling sites. MA and AMP concentrations in the left and right testes correlated with concentrations in iliac vein blood, but not with concentrations in urine. Conversely, MA and AMP concentrations in the prostate did not correlate with concentrations in any body fluid samples. Concentrations of MA were much higher in the left and right testes and prostate than in right heart and iliac vein blood (median, about 3–5 times higher). Concentrations of AMP were also much higher in the left and right testes and prostate than in right heart and iliac vein blood (median, about 2–3 times higher). In conclusion, this study revealed that MA and AMP were detected in the left and right testes and prostate at median concentrations about 2–5 times higher than those in blood.</div></div>","PeriodicalId":49913,"journal":{"name":"Legal Medicine","volume":"75 ","pages":"Article 102618"},"PeriodicalIF":1.3000,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Forensic significance of quantitatively analyzing methamphetamine in male reproductive organs\",\"authors\":\"Naoto Tani, Shigeki Oritani, Mayumi Ono, Takaki Ishikawa\",\"doi\":\"10.1016/j.legalmed.2025.102618\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The present study measured concentrations of methamphetamine (MA) and its metabolite amphetamine (AMP) in male reproductive organs and investigated the significance of detecting these stimulants in the reproductive organs and the associated pharmacokinetics. The study examined the left and right testes and prostate from 28 male autopsy cases in which MA had been detected. Concentrations of MA and AMP in the left and right testes and prostate were quantified and compared with concentrations in right heart blood, iliac vein blood, and urine. No correlations were found between MA or AMP concentrations and post-mortem time at any sampling sites. MA and AMP concentrations in the left and right testes correlated with concentrations in iliac vein blood, but not with concentrations in urine. Conversely, MA and AMP concentrations in the prostate did not correlate with concentrations in any body fluid samples. Concentrations of MA were much higher in the left and right testes and prostate than in right heart and iliac vein blood (median, about 3–5 times higher). Concentrations of AMP were also much higher in the left and right testes and prostate than in right heart and iliac vein blood (median, about 2–3 times higher). In conclusion, this study revealed that MA and AMP were detected in the left and right testes and prostate at median concentrations about 2–5 times higher than those in blood.</div></div>\",\"PeriodicalId\":49913,\"journal\":{\"name\":\"Legal Medicine\",\"volume\":\"75 \",\"pages\":\"Article 102618\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2025-04-11\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Legal Medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1344622325000525\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MEDICINE, LEGAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Legal Medicine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1344622325000525","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, LEGAL","Score":null,"Total":0}

引用次数: 0

摘要

本研究测定了男性生殖器官中甲基苯丙胺（MA）及其代谢物安非他明（AMP）的浓度，探讨了在生殖器官中检测这些兴奋剂的意义及其药代动力学。该研究检查了28例男性尸检中检测到MA的左右睾丸和前列腺。定量测定左、右睾丸和前列腺中MA和AMP的浓度，并与右心血、髂静脉血和尿液中的浓度进行比较。在任何取样地点，MA或AMP浓度与死后时间之间均未发现相关性。左、右睾丸MA和AMP浓度与髂静脉血浓度相关，但与尿浓度无关。相反，前列腺中的MA和AMP浓度与任何体液样本中的浓度无关。左、右睾丸和前列腺的MA浓度明显高于右心脏和髂静脉血液（中位数，约为3-5倍）。左右睾丸和前列腺的AMP浓度也远高于右心脏和髂静脉血液（中位数，约高2-3倍）。综上所述，本研究发现左、右睾丸和前列腺中均检测到MA和AMP，中位浓度约为血液中浓度的2-5倍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Forensic significance of quantitatively analyzing methamphetamine in male reproductive organs

The present study measured concentrations of methamphetamine (MA) and its metabolite amphetamine (AMP) in male reproductive organs and investigated the significance of detecting these stimulants in the reproductive organs and the associated pharmacokinetics. The study examined the left and right testes and prostate from 28 male autopsy cases in which MA had been detected. Concentrations of MA and AMP in the left and right testes and prostate were quantified and compared with concentrations in right heart blood, iliac vein blood, and urine. No correlations were found between MA or AMP concentrations and post-mortem time at any sampling sites. MA and AMP concentrations in the left and right testes correlated with concentrations in iliac vein blood, but not with concentrations in urine. Conversely, MA and AMP concentrations in the prostate did not correlate with concentrations in any body fluid samples. Concentrations of MA were much higher in the left and right testes and prostate than in right heart and iliac vein blood (median, about 3–5 times higher). Concentrations of AMP were also much higher in the left and right testes and prostate than in right heart and iliac vein blood (median, about 2–3 times higher). In conclusion, this study revealed that MA and AMP were detected in the left and right testes and prostate at median concentrations about 2–5 times higher than those in blood.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Legal Medicine Nursing-Issues, Ethics and Legal Aspects

CiteScore

2.80

自引率

6.70%

发文量

119

审稿时长

7.9 weeks

期刊介绍： Legal Medicine provides an international forum for the publication of original articles, reviews and correspondence on subjects that cover practical and theoretical areas of interest relating to the wide range of legal medicine. Subjects covered include forensic pathology, toxicology, odontology, anthropology, criminalistics, immunochemistry, hemogenetics and forensic aspects of biological science with emphasis on DNA analysis and molecular biology. Submissions dealing with medicolegal problems such as malpractice, insurance, child abuse or ethics in medical practice are also acceptable.