老年女性亚临床抑郁症患者内在脑活动的时间动态。

Jing Jiang,Lei Li,Xueling Suo,Taolin Chen,Stefania Ferraro,Jin Gao,Dongmei Wu,Song Wang
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引用次数: 0

摘要

亚临床抑郁症在老年人中很常见,尤其是在女性中,并且可能与较高的健康事件可能性和不良预后相关。然而,潜在的神经生物学仍不清楚。本研究采用静息状态功能磁共振成像(rs-fMRI),确定了阈下抑郁症(OWSD)老年妇女内在脑活动的时间动态变化及其与抑郁症状的潜在关系。应用滑动窗口法评估50例老年女性和52例健康老年女性对照的rs-fMRI指标的时间变化,包括低频波动幅度(ALFF)、低频波动分数幅度(fALFF)、区域均匀性(ReHo)和度中心性(DC)。然后,我们计算了rs-fMRI指数的动态体素一致性指数。采用相关分析评估动态指标与抑郁症状之间的相关性。我们发现,相对于HOWC, OWSD显示左侧背外侧前额叶皮层(DLPFC)的动态ALFF (dALFF)显著增加。在脑区域功能整合方面,OWSD显示右侧顶叶的动态体素一致性指数显著降低,主要包括楔前叶和顶叶上小叶,延伸到中央后回。区域dALFF和动态一致性指数变化与抑郁症状相关。综上所述,强迫症表现出与抑郁相关的内在脑活动的时间变异性改变,以及脑功能整合的区域性缺陷。这些发现加强了我们对老年妇女阈下抑郁精神病理的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Temporal dynamics of intrinsic brain activity in older women with subclinical depression.
Subclinical depression is common in older adults, especially in females, and may correlate with a higher likelihood of health events and poor prognosis. However, the underlying neurobiology remains unclear. This study, employing resting-state functional magnetic resonance imaging (rs-fMRI), identified alterations in temporal dynamics of intrinsic brain activity in older women with subthreshold depression (OWSD) and their potential relationships to depressive symptoms. The sliding window approach was applied to evaluate the temporal variations of the rs-fMRI indices, including the amplitude of low-frequency fluctuation (ALFF), the fractional amplitude of low-frequency fluctuation (fALFF), regional homogeneity (ReHo), and degree centrality (DC) in 50 OWSD and 52 healthy older women controls (HOWC). We then calculated the dynamic voxel-wise concordance index of the rs-fMRI indices. The correlational analyses were used to assess the correlations between the dynamic indices and depressive symptoms. We found that OWSD showed a significant increase in dynamic ALFF (dALFF) in the left dorsolateral prefrontal cortex (DLPFC) relative to HOWC. With respect to regional brain function integration, OWSD showed a significantly lower dynamic voxel-wise concordance index in the right parietal lobe, mainly including the precuneus and superior parietal lobule extending to the postcentral gyrus. The regional dALFF and dynamic concordance index alterations were correlated with depressive symptoms. In conclusion, OWSD showed depression-correlated alterations in temporal variability of intrinsic brain activity, along with regional deficits in brain function integration. The findings reinforce our understanding of subthreshold depression psychopathology in older women.
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