双响应荧光探针Rh-O-QL同时监测线粒体自噬过程中NAD(P)H和pH

IF 4.3 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-04-18 DOI:10.1039/d5cc00961h

Liandi Guan, Wanting Hu, Shiyu Zhang, Yongjian Ai, Qionglin Liang

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引用次数: 0

摘要

线粒体自噬与异常的NAD(P)H和pH密切相关。在这里，我们合成了一种双反应荧光探针，对NAD(P)H具有高选择性和对生理pH范围的敏感性，用于线粒体NAD(P)H和pH的同时成像分析，有望成为了解线粒体相关疾病的新工具。

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A dual-response fluorescent probe Rh-O-QL for simultaneous monitoring NAD(P)H and pH during mitochondrial autophagy

Mitochondrial autophagy is closely related to abnormal NAD(P)H and pH. Here, we synthesized a dual-response fluorescent probe with high selectivity for NAD(P)H and sensitivity for physiological pH range, for simultaneous imaging analysis of mitochondrial NAD(P)H and pH, holding potential as a novel tool for understanding mitochondria-associated diseases.

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.