提取物裂解细菌病原体

IF 20.5 1区生物学 Q1 MICROBIOLOGY

Nature Microbiology Pub Date : 2025-04-18 DOI:10.1038/s41564-025-01995-9

Mahyar Aghapour, Lina Herhaus

引用次数: 0

摘要

aaa - atp酶，p97，结合泛素化的细菌表面蛋白，用机械力提取它们，破坏和裂解细菌的细胞包膜。因此，泛素化和蛋白酶体靶向提供了细胞对胞质内病原体的自主免疫。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Extract to lyse bacterial pathogens

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Extract to lyse bacterial pathogens

The AAA-ATPase, p97, binds ubiquitinated bacterial surface proteins, extracting them with a mechanical force that disrupts and lyses the bacterial cell envelope. Thus, ubiquitination and proteasomal targeting provide cell autonomous immunity against cytosolic intracellular pathogens.

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来源期刊

Nature Microbiology Immunology and Microbiology-Microbiology

CiteScore

44.40

自引率

1.10%

发文量

226

期刊介绍： Nature Microbiology aims to cover a comprehensive range of topics related to microorganisms. This includes: Evolution: The journal is interested in exploring the evolutionary aspects of microorganisms. This may include research on their genetic diversity, adaptation, and speciation over time. Physiology and cell biology: Nature Microbiology seeks to understand the functions and characteristics of microorganisms at the cellular and physiological levels. This may involve studying their metabolism, growth patterns, and cellular processes. Interactions: The journal focuses on the interactions microorganisms have with each other, as well as their interactions with hosts or the environment. This encompasses investigations into microbial communities, symbiotic relationships, and microbial responses to different environments. Societal significance: Nature Microbiology recognizes the societal impact of microorganisms and welcomes studies that explore their practical applications. This may include research on microbial diseases, biotechnology, or environmental remediation. In summary, Nature Microbiology is interested in research related to the evolution, physiology and cell biology of microorganisms, their interactions, and their societal relevance.