中性粒细胞衰老驱动膀胱癌的两性二态性

IF 27.7 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2025-04-18 DOI:10.1038/s41590-025-02133-7

引用次数: 0

摘要

我们发现了一个与年龄相关的RETNLγ+LCN2+衰老样中性粒细胞（RLSNs）亚群，它们优先在雄性小鼠和人类的肿瘤微环境中积累。RLSNs具有很强的免疫抑制功能，限制抗肿瘤免疫，可能是膀胱癌中两性异形的一种机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Neutrophil senescence drives sexual dimorphism in bladder cancer

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Neutrophil senescence drives sexual dimorphism in bladder cancer

We identify an age-related subpopulation of RETNLγ+LCN2+ senescence-like neutrophils (RLSNs) that preferentially accumulate in the tumor microenvironment of male mice and humans. RLSNs exert strong immunosuppressive functions and limit antitumor immunity, and may represent a mechanism to explain sexual dimorphism in bladder cancer.

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来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.