α-亚胺酮的芳基化及其与烯丙酸酯的环化：直接接触位阻吡咯

IF 2.8 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2025-04-01 DOI:10.1002/ajoc.202400756

Srinivasarao Yaragorla , Doma Arun

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引用次数: 0

摘要

在这里，我们报道了一个钙催化的，一锅，四组分的反应来合成不同取代的吡咯。这种原子经济反应包括一系列的反应，包括α -亚胺酮的原位生成、Friedel-Crafts芳构化、氮杂环化和芳构化。该反应显示出广泛的底物范围和良好的收率。我们展示了克级合成和合成后修饰。

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Arylation of α‐Imino Ketones and their Cyclization with Allenoates: Direct Access to Sterically Hindered Pyrroles

Herein, we report a calcium‐catalyzed, one‐pot, four‐component reaction to synthesize diversely substituted pyrroles. This atom‐economy reaction involves a sequence of reactions that proceed via in situ formation of α ‐ imino ketones, Friedel‐Crafts arylation, aza‐cyclization, and aromatization in the single pot. The reaction showed a broad substrate scope with good yields. We demonstrated the gram‐scale synthesis and post‐synthetic modifications.

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.