LIMA1 o - glcn酰化通过诱导β-连环蛋白调控的FASn在代谢功能障碍相关的脂肪变性肝病中的表达促进肝脏脂质沉积（Adv. Sci. 15/2025）

IF 14.3 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Science Pub Date : 2025-04-17 DOI:10.1002/advs.202570110

Fuji Yang, Yifei Chen, Guojun Zheng, Kefeng Gu, Lin Fan, Tingfen Li, Ling Zhu, Yongmin Yan

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引用次数: 0

摘要

高脂肪饮食上调肝细胞中LIMA1的o- glcn酰化和LIMA1富集的小细胞外囊泡（sEV）分泌，加剧肝脂质沉积和代谢功能障碍相关的脂肪性肝炎（MASH）纤维化。LIMA1是一种很有前途的非侵入性生物标志物和治疗靶点。更多的细节可以在第2415941号文章中找到闫永敏和他的同事。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

LIMA1 O-GlcNAcylation Promotes Hepatic Lipid Deposition through Inducing β-catenin-Regulated FASn Expression in Metabolic Dysfunction-Associated Steatotic Liver Disease (Adv. Sci. 15/2025)

查看原文本刊更多论文

LIMA1 O-GlcNAcylation Promotes Hepatic Lipid Deposition through Inducing β-catenin-Regulated FASn Expression in Metabolic Dysfunction-Associated Steatotic Liver Disease (Adv. Sci. 15/2025)

Dysfunction-Associated Steatotic Liver Disease

High-fat diet upregulated O-GlcNAcylation of LIMA1 and LIMA1-enriched small extracellular vesicle (sEV) secretion in hepatocytes, exacerbated hepatic lipid deposition and metabolic dysfunction-associated steato-hepatitis (MASH) fibrosis. LIMA1 is a promising non-invasive biomarker and therapeutic target for MASH. More details can be found in article number 2415941 by Yongmin Yan and co-workers.

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来源期刊

Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

18.90

自引率

2.60%

发文量

1602

审稿时长

1.9 months

期刊介绍： Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.