结合宿主导向疗法和抗生素的纳米颗粒提高感染海洋分枝杆菌的斑马鱼胚胎的细菌杀伤和总体存活率（ad . therapp . 4/2025）

IF 3.7 4区医学 Q2 PHARMACOLOGY & PHARMACY

Advanced Therapeutics Pub Date : 2025-04-18 DOI:10.1002/adtp.202570009

Gabriela Schäfer, Dongdong Bi, Federico Fenaroli, Andrew M. Thompson, Anno Saris, Matthias Barz

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引用次数: 0

摘要

结核病（TB）是一种由结核分枝杆菌引起的高度复杂、异质性、难以治愈的感染。由于抗生素和疫苗的治疗效果仍然有限，结核病仍然是一个全球性的问题。在文章2400174中，Andrew M. Thompson， Matthias Barz及其同事证明了抗生素和宿主定向治疗多肽(o)ide胶束的结合可以完全根除细胞和斑马鱼结核病模型中的细菌感染。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Nanoparticles Combining Host-Directed Therapeutics and Antibiotics to Boost Bacterial Killing and Overall Survival of Zebrafish Embryos Infected with Mycobacterium Marinum (Adv. Therap. 4/2025)

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Nanoparticles Combining Host-Directed Therapeutics and Antibiotics to Boost Bacterial Killing and Overall Survival of Zebrafish Embryos Infected with Mycobacterium Marinum (Adv. Therap. 4/2025)

Tuberculosis (TB) is a highly complex, heterogenous and thus hardly curable infection caused by the Mycobacterium Tuberculosis. Since the therapeutic efficacy of antibiotics and vaccines remains limited, TB remains a global thread. In article 2400174, Andrew M. Thompson, Matthias Barz, and co-workers demonstrate that the combination of antibiotics and host directed therapeutics in polypeptides(o)ide micelles can completely eradicate bacterial infections in cell and zebrafish models of tuberculosis.

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来源期刊

Advanced Therapeutics Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

7.10

自引率

2.20%

发文量

130