dbu介导的3-氯吲哚与9-黄原基芴反应合成3-芳基氧吲哚

IF 2.8 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2025-04-01 DOI:10.1002/ajoc.202400660

Nitchakan Purahong , Dr. Thapong Teerawatananond , Dr. Nawasit Chotsaeng , Pattarapapa Janthakit , Phattananawee Nalaoh , Prof. Dr. Vinich Promarak , Prof. Dr. Chutima Kuhakarn , Dr. Jatuporn Meesin

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引用次数: 0

摘要

本文报道了以1,8-重氮双环[5.4.0]十一-7-烯（DBU）为载体，通过3-氯代吲哚与o -乙基S-（9h -芴-9-基）羰基二硫代酸盐反应合成3-（9h -芴-9-基）吲哚-2- 1衍生物的新途径。该反应在室温下容易进行，可以在短的反应时间内（15分钟）制备3-烯基氧吲哚。通过NaBH4还原，3-烯基氧吲哚很容易转化为3-芴基氧吲哚。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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DBU‐Mediated Reaction of 3‐Chlorooxindole and 9‐Xanthyl Fluorene for Synthesis of 3‐Arylidene Oxindole

This work reports a new route for the synthesis of 3‐(9H‐fluoren‐9‐ylidene)indolin‐2‐one derivatives via the reaction of 3‐chlorooxindoles and O‐ethyl S‐(9H‐fluoren‐9‐yl) carbonodithioates mediated by 1,8‐diazabicyclo[5.4.0]undec‐7‐ene (DBU). The reactions readily proceeded at room temperature, enable a collection of 3‐alkenyl oxindoles to be prepared within a short reaction time (15 minutes). The 3‐alkenyl oxindoles can be easily converted to 3‐fluorenyl oxindoles by NaBH₄ reduction.

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.