钌催化二腈与伯醇的反应以合成 N-烷基化环状 β-烯氨基二腈

IF 2.8 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2025-04-01 DOI:10.1002/ajoc.202400730

Prof. Wei Ma , Qiang Zhao , Shibin Su , Weiwei Zhang , Yao Yao , Pei Wang , Dr. Dong Tang , Dr. Pengjuan Zhou

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引用次数: 0

摘要

本文提出了一种利用易得的脂肪二腈和伯醇一锅合成n -烷基化环β-氨基腈的新方法。该方法利用Ru-MACHO络合物催化剂（1mol %）与强碱和非极性溶剂结合，具有广泛的底物范围和良好的官能团耐受性。这个过程是高度原子经济的，产生水作为唯一的副产品。以优异的收率合成了一系列n -烷基化环β-胺腈，并成功地将该方法扩大到克级合成。

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Ruthenium‐catalyzed reaction of dinitriles with primary alcohols for the synthesis of N‐alkylated cyclic β‐enaminonitriles

A novel one‐pot synthetic approach for preparing N‐alkylated cyclic β‐enaminonitriles has been developed using readily available aliphatic dinitriles and primary alcohols. This method utilizes a Ru‐MACHO complex catalyst (1 mol%) in conjunction with a strong base and a nonpolar solvent, exhibiting a broad substrate scope and excellent functional group tolerance. The process is highly atom economic, producing water as the sole by‐produc. A range of N‐alkylated cyclic β‐enaminonitriles were synthesized in good to excellent yields, and the method was successfully scaled up to gram‐scale synthesis.

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.